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Commd3 Gene Detail
Summary
  • Symbol
    Commd3
  • Name
    COMM domain containing 3
  • Synonyms
    Bup, D2Ertd542e
  • Feature Type
    protein coding gene
  • IDs
    MGI:88218
    NCBI Gene: 12238
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:18677246-18681042 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 12.90 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    106 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88218
 protein coding gene Chr2:18677234-18681042 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025375
 protein coding gene Chr2:16386606-16390803 (+)
A/J MGP_AJ_G0025353
 protein coding gene Chr2:15724440-15728226 (+)
AKR/J MGP_AKRJ_G0025321
 protein coding gene Chr2:16243066-16246853 (+)
BALB/cJ MGP_BALBcJ_G0025348
 protein coding gene Chr2:15747716-15751492 (+)
C3H/HeJ MGP_C3HHeJ_G0025108
 protein coding gene Chr2:16172561-16176964 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025791
 protein coding gene Chr2:16800452-16804282 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023206
 protein coding gene Chr2:15115159-15119011 (+)
CAST/EiJ MGP_CASTEiJ_G0024572
 protein coding gene Chr2:16135365-16139227 (+)
CBA/J MGP_CBAJ_G0025087
 protein coding gene Chr2:17558265-17562074 (+)
DBA/2J MGP_DBA2J_G0025219
 protein coding gene Chr2:15648090-15651936 (+)
FVB/NJ MGP_FVBNJ_G0025182
 protein coding gene Chr2:15446942-15450734 (+)
LP/J MGP_LPJ_G0025306
 protein coding gene Chr2:16220925-16224729 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025213
 protein coding gene Chr2:17517864-17524721 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025849
 protein coding gene Chr2:16196667-16202656 (+)
PWK/PhJ MGP_PWKPhJ_G0024321
 protein coding gene Chr2:15522413-15526507 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024121
 protein coding gene Chr2:16329138-16332991 (+)
WSB/EiJ MGP_WSBEiJ_G0024642
 protein coding gene Chr2:16255866-16259645 (+)



Homology
more
  • Human Ortholog
    COMMD3, COMM domain containing 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    COMMD3, COMM domain containing 3
  • Synonyms
    BUP, C10orf8
  • Links
    NCBI Gene ID: 23412
    neXtProt AC: NX_Q9UBI1
    UniProt: Q9UBI1

  • Chr Location
    10p12.2; chr10:22316386-22320306 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in B cells exhibit impaired B cell migration and humoral immune responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    733
  • Tissues
    14
  • cDNA Data
    120
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12238 NCBI Gene Model | MGI Sequence Detail 3797 C57BL/6J ±  kb
    transcript NM_147778 RefSeq | MGI Sequence Detail 923 ZRU/MplStud  
    polypeptide Q63829 UniProt | EBI | MGI Sequence Detail 195 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 122
      cDNA 121
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-1685, MGI:1261851, MGI:2139387
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 5
    • Earliest
      J:15805 Haupt Y, et al., Nucleotide sequence of bup, an upstream gene in the bmi-1 proviral insertion locus. Mol Biol Rep. 1992 Nov;17(1):17-20
    • Latest
      J:337427 Shirai T, et al., Celastrol suppresses humoral immune responses and autoimmunity by targeting the COMMD3/8 complex. Sci Immunol. 2023 Mar 31;8(81):eadc9324
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory