Camk2a MGI Mouse Gene Detail - MGI:88256 - calcium/calmodulin-dependent protein kinase II alpha

Symbol

Camk2a
Name

calcium/calmodulin-dependent protein kinase II alpha
Synonyms

alpha-CaMKII, mKIAA0968

Feature Type

protein coding gene
IDs

MGI:88256
NCBI Gene: 12322
Alliance

gene page
Transcription Start Sites

25 TSS

Sequence Map

Chr18:61058704-61121224 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 34.41 cM
Mapping Data

5 experiments

SNPs within 2kb

1959 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88256	protein coding gene	Chr18:61058690-61121224 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024471	protein coding gene	Chr18:60773163-60843362 (+)
A/J	MGP_AJ_G0024438	protein coding gene	Chr18:58169121-58233458 (+)
AKR/J	MGP_AKRJ_G0024408	protein coding gene	Chr18:59770918-59839109 (+)
BALB/cJ	MGP_BALBcJ_G0024437	protein coding gene	Chr18:58293837-58358881 (+)
C3H/HeJ	MGP_C3HHeJ_G0024205	protein coding gene	Chr18:60001492-60065667 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024884	protein coding gene	Chr18:62429931-62495897 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022315	protein coding gene	Chr18:57712772-57776733 (+)
CAST/EiJ	MGP_CASTEiJ_G0023678	protein coding gene	Chr18:59865852-59934499 (+)
CBA/J	MGP_CBAJ_G0024175	protein coding gene	Chr18:64439349-64501267 (+)
DBA/2J	MGP_DBA2J_G0024305	protein coding gene	Chr18:57841389-57904298 (+)
FVB/NJ	MGP_FVBNJ_G0024271	protein coding gene	Chr18:57245290-57311141 (+)
LP/J	MGP_LPJ_G0024388	protein coding gene	Chr18:60622500-60691134 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024300	protein coding gene	Chr18:66068325-66132271 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024931	protein coding gene	Chr18:59963881-60031641 (+)
PWK/PhJ	MGP_PWKPhJ_G0023421	protein coding gene	Chr18:58066388-58130161 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023227	protein coding gene	Chr18:60197976-60260747 (+)
WSB/EiJ	MGP_WSBEiJ_G0023742	protein coding gene	Chr18:59820424-59887849 (+)

Human Ortholog

CAMK2A, calcium/calmodulin dependent protein kinase II alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CAMK2A, calcium/calmodulin dependent protein kinase II alpha
Synonyms

CAMKA, CaMKIIalpha, CaMKIINalpha, MRD53, MRT63
Links

HGNC:1460

NCBI Gene ID: 815

neXtProt AC: NX_Q9UQM7

UniProt: Q9UQM7
Chr Location

5q32; chr5:150219491-150290130 (-) GRCh38

MGI Vertebrate Homology

Camk2a stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CAMK2A
Gene Tree

Camk2a

Diseases

2 with Camk2a mouse models; 2 with human CAMK2A associations

Human Disease

Mouse Models

autism spectrum disorder

IDs

View 1 model

bipolar disorder

IDs

View 1 model

autosomal dominant intellectual developmental disorder 53

IDs

autosomal recessive intellectual developmental disorder 63

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

55 phenotypes from 12 alleles in 16 genetic backgrounds
14 phenotypes from multigenic genotypes
1 images
102 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

53
Chemically induced (ENU)

1
Endonuclease-mediated

7
Gene trapped

23
Targeted

15
Transgenic

7
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

135 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous targeted mutants display deficient long-term hippocampal potentiation (LTP) and specific impairment in spatial learning; heterozygotes show decreased fear response and increased defensive aggression, which is more pronounced in homozygotes.

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All GO Annotations

86
GO References

29

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1185
Tissues

120
cDNA Data

13
Literature Summary

43

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CAMK2A

Xenbase camk2a

ZFIN camk2a

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All Sequences

62
RefSeq

10
UniProt

6
CCDS

CCDS29276.1, CCDS29277.1, CCDS70898.1

Ensembl

ENSMUSG00000024617 (Evidence)
NCBI Gene

12322

			Length	Strain/Species	Flank
genomic	12322	NCBI Gene Model \| MGI Sequence Detail	62521	C57BL/6J	± kb
transcript	NM_001403309	RefSeq \| MGI Sequence Detail	4989	ZRU/MplStud
polypeptide	P11798	UniProt \| EBI \| MGI Sequence Detail	478	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000003199 calcium/calmodulin-dependent protein kinase type II subunit alpha

(term hierarchy)
PDB

1HKX, 4X3I, 6TS3, 7B55, 7B56, 7B57
EC

2.7.11.17
InterPro Domains

IPR013543 Calcium/calmodulin-dependent protein kinase II, association-domain

IPR032710 NTF2-like domain superfamily

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site
GlyGen

P11798 6 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (4 sites)

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All nucleic 20

Genomic 1

cDNA 15

Primer pair 4

Microarray probesets 7

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MGD-MRK-1743, MGI:2147420

Summaries

All 317

Developmental Gene Expression 43

Diseases 2

Gene Ontology 29

Phenotypes 102
Earliest

J:9840 Hanley RM, et al., Sequence of the cDNA for the alpha subunit of calmodulin kinase II from mouse brain. Nucleic Acids Res. 1989 May 25;17(10):3992
Latest

J:347984 Naillat F, et al., Calcium signaling induces partial EMT and renal fibrosis in a Wnt4(mCherry) knock-in mouse model. Biochim Biophys Acta Mol Basis Dis. 2024 Apr 21;1870(5):167180

TSS for Camk2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151368	Chr18:61058684-61058711 (+)	-6 bp
Tssr151369	Chr18:61058716-61058727 (+)	18 bp
Tssr151370	Chr18:61096589-61096675 (+)	37,928 bp
Tssr151371	Chr18:61096687-61096698 (+)	37,989 bp
Tssr151372	Chr18:61096723-61096728 (+)	38,022 bp
Tssr151373	Chr18:61096847-61096908 (+)	38,174 bp
Tssr151374	Chr18:61096930-61096935 (+)	38,229 bp
Tssr151375	Chr18:61102728-61102752 (+)	44,036 bp
Tssr5345	Chr18:61117206-61117215 (+)	58,507 bp
Tssr151376	Chr18:61117381-61117404 (+)	58,689 bp
Tssr151377	Chr18:61117460-61117472 (+)	58,762 bp
Tssr151378	Chr18:61117509-61117523 (+)	58,812 bp
Tssr151379	Chr18:61118742-61118754 (+)	60,044 bp
Tssr151380	Chr18:61118814-61118825 (+)	60,116 bp
Tssr151381	Chr18:61118848-61118857 (+)	60,149 bp
Tssr151382	Chr18:61118952-61118969 (+)	60,257 bp
Tssr151383	Chr18:61118988-61118999 (+)	60,290 bp
Tssr151384	Chr18:61119034-61119041 (+)	60,334 bp
Tssr151385	Chr18:61119074-61119091 (+)	60,379 bp
Tssr151386	Chr18:61119134-61119143 (+)	60,435 bp
Tssr151387	Chr18:61119174-61119182 (+)	60,474 bp
Tssr151388	Chr18:61119191-61119206 (+)	60,495 bp
Tssr151389	Chr18:61120601-61120620 (+)	61,907 bp
Tssr151390	Chr18:61120818-61120857 (+)	62,134 bp
Tssr151391	Chr18:61121006-61121009 (+)	62,304 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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