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Capn2 Gene Detail
Summary
  • Symbol
    Capn2
  • Name
    calpain 2
  • Synonyms
    Capa-2, Capa2, m-calpain
  • Feature Type
    protein coding gene
  • IDs
    MGI:88264
    NCBI Gene: 12334
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:182294825-182345173 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 84.93 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1821 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88264
 protein coding gene Chr1:182294818-182345175 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016895
 protein coding gene Chr1:189097610-189151059 (-)
A/J MGP_AJ_G0016874
 protein coding gene Chr1:181390308-181441443 (-)
AKR/J MGP_AKRJ_G0016839
 protein coding gene Chr1:186765703-186815144 (-)
BALB/cJ MGP_BALBcJ_G0016832
 protein coding gene Chr1:182023582-182073899 (-)
C3H/HeJ MGP_C3HHeJ_G0016656
 protein coding gene Chr1:187582392-187632462 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017295
 protein coding gene Chr1:195197873-195249742 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015002
 protein coding gene Chr1:172460485-172511865 (-)
CAST/EiJ MGP_CASTEiJ_G0016238
 protein coding gene Chr1:186925861-186980702 (-)
CBA/J MGP_CBAJ_G0016630
 protein coding gene Chr1:202442205-202496305 (-)
DBA/2J MGP_DBA2J_G0016736
 protein coding gene Chr1:180167584-180217095 (-)
FVB/NJ MGP_FVBNJ_G0016732
 protein coding gene Chr1:178304419-178354948 (-)
LP/J MGP_LPJ_G0016811
 protein coding gene Chr1:190291343-190341729 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016764
 protein coding gene Chr1:209448523-209499676 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017332
 protein coding gene Chr1:186593762-186646078 (-)
PWK/PhJ MGP_PWKPhJ_G0016026
 protein coding gene Chr1:179355333-179408492 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015802
 protein coding gene Chr1:185553932-185605041 (-)
WSB/EiJ MGP_WSBEiJ_G0016301
 protein coding gene Chr1:186787594-186841148 (-)



Homology
more
  • Human Ortholog
    CAPN2, calpain 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAPN2, calpain 2
  • Synonyms
    CANP2, CANPL2, CANPml, mCANP
  • Links
    NCBI Gene ID: 824
    neXtProt AC: NX_P17655
    UniProt: P17655

  • Chr Location
    1q41; chr1:223701593-223776018 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotypes from multigenic genotypes
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene leads to complete prenatal lethality. Mice homozygous for one null allele display placental dysfunction, thin ventricular walls, and peripheral vessel failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    784
  • Tissues
    39
  • cDNA Data
    172
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026509 Ensembl Gene Model | MGI Sequence Detail 50349 C57BL/6J ±  kb
    transcript ENSMUST00000068505 Ensembl | MGI Sequence Detail 3225 Not Applicable  
    polypeptide ENSMUSP00000068895 Ensembl | MGI Sequence Detail 700 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 177
      cDNA 175
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1751, MGD-MRK-1755, MGI:2138213
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 12
      Gene Ontology 19
      Phenotypes 7
    • Earliest
      J:10758 Ohno S, et al., Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53(4):225-9
    • Latest
      J:348877 Wang LH, et al., Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration. J Neurosci. 2022 Jun 22;42(25):5102-5114
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory