About   Help   FAQ
Ctnna2 Gene Detail
Summary
  • Symbol
    Ctnna2
  • Name
    catenin alpha 2
  • Synonyms
    alpha N-catenin, alpha(N)-catenin, Catna, Catna2, chp
  • Feature Type
    protein coding gene
  • IDs
    MGI:88275
    NCBI Gene: 12386
  • Alliance
    gene page
  • Transcription Start Sites
    18 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:76858620-77956682 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 33.54 cM, cytoband B3-D
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32554 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88275
 protein coding gene Chr6:76858620-77956798 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030890
 protein coding gene Chr6:77650108-78797283 (-)
A/J MGP_AJ_G0030859
 protein coding gene Chr6:74588154-75696758 (-)
AKR/J MGP_AKRJ_G0030788
 protein coding gene Chr6:76834923-77985338 (-)
BALB/cJ MGP_BALBcJ_G0030870
 protein coding gene Chr6:74684495-75793266 (-)
C3H/HeJ MGP_C3HHeJ_G0030841
 protein coding gene Chr6:106317009-107455587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031328
 protein coding gene Chr6:79710107-80889790 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028517
 protein coding gene Chr6:73474265-74556812 (-)
CAST/EiJ MGP_CASTEiJ_G0029978
 protein coding gene Chr6:76746801-77912098 (-)
CBA/J MGP_CBAJ_G0030557
 protein coding gene Chr6:82890588-84100646 (-)
DBA/2J MGP_DBA2J_G0030709
 protein coding gene Chr6:73973336-75099327 (-)
FVB/NJ MGP_FVBNJ_G0030662
 protein coding gene Chr6:73273285-74360415 (-)
LP/J MGP_LPJ_G0030789
 protein coding gene Chr6:77560823-78717148 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030697
 protein coding gene Chr6:86847849-88092281 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031354
 protein coding gene Chr6:76677223-77807124 (-)
PWK/PhJ MGP_PWKPhJ_G0029694
 protein coding gene Chr6:72943792-74057178 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029522
 protein coding gene Chr6:75457518-76607549 (-)
WSB/EiJ MGP_WSBEiJ_G0030060
 protein coding gene Chr6:77049018-78196641 (-)



Homology
more
  • Human Ortholog
    CTNNA2, catenin alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTNNA2, catenin alpha 2
  • Synonyms
    CAP-R, CAPR, CDCBM9, CT114, CTNR
  • Links
    NCBI Gene ID: 1496
    neXtProt AC: NX_P26232
    UniProt: P26232

  • Chr Location
    2p12; chr2:79185231-80648861 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CTNNA2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation of this gene exhibit ataxia, reduced body weight, reduced male fertility, and abnormalities of the brain which include a hypoplastic cerebellum, abnormal foliation pattern, ectopic Purkinje cells, and abnormal pyramidal cells in the hippocampus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1165
  • Tissues
    192
  • cDNA Data
    61
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063063 Ensembl Gene Model | MGI Sequence Detail 1098063 C57BL/6J ±  kb
    transcript ENSMUST00000160894 Ensembl | MGI Sequence Detail 4162 Not Applicable  
    polypeptide ENSMUSP00000124764 Ensembl | MGI Sequence Detail 966 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 67
      cDNA 63
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1772, MGD-MRK-1774, MGD-MRK-1973, MGD-MRK-36040, MGI:107473, MGI:2141432
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 44
      Diseases 1
      Gene Ontology 18
      Phenotypes 19
    • Earliest
      J:37373 Ozawa M, et al., The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J. 1989 Jun;8(6):1711-7
    • Latest
      J:326946 Martin JB, et al., Arvcf Dependent Adherens Junction Stability is Required to Prevent Age-Related Cortical Cataracts. Front Cell Dev Biol. 2022;10:840129
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory