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Ms4a1 Gene Detail
Summary
  • Symbol
    Ms4a1
  • Name
    membrane-spanning 4-domains, subfamily A, member 1
  • Synonyms
    Cd20, Ly-44
  • Feature Type
    protein coding gene
  • IDs
    MGI:88321
    NCBI Gene: 12482
  • Member of
    Ms4ac cluster
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11227043-11243513 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.19 cM, cytoband B
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88321
 protein coding gene Chr19:11227039-11243605 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024873
 protein coding gene Chr19:8628796-8645254 (-)
A/J MGP_AJ_G0024841
 protein coding gene Chr19:8068389-8085691 (-)
AKR/J MGP_AKRJ_G0024816
 protein coding gene Chr19:8365473-8382979 (-)
BALB/cJ MGP_BALBcJ_G0024841
 protein coding gene Chr19:8103233-8120262 (-)
C3H/HeJ MGP_C3HHeJ_G0024607
 protein coding gene Chr19:8255220-8275613 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025289
 protein coding gene Chr19:9020807-9039416 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022716
 protein coding gene Chr19:8473676-8490167 (-)
CAST/EiJ MGP_CASTEiJ_G0024080
 protein coding gene Chr19:7896182-7914219 (-)
CBA/J MGP_CBAJ_G0024581
 protein coding gene Chr19:9070783-9089943 (-)
DBA/2J MGP_DBA2J_G0024708
 protein coding gene Chr19:8058694-8081691 (-)
FVB/NJ MGP_FVBNJ_G0024675
 protein coding gene Chr19:8091425-8107844 (-)
LP/J MGP_LPJ_G0024795
 protein coding gene Chr19:8585547-8603886 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024702
 protein coding gene Chr19:8957163-8973787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025337
 protein coding gene Chr19:8397533-8415486 (-)
PWK/PhJ MGP_PWKPhJ_G0023824
 protein coding gene Chr19:7503750-7520761 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023630
 protein coding gene Chr19:7591007-7607995 (-)
WSB/EiJ MGP_WSBEiJ_G0024142
 protein coding gene Chr19:8286925-8309529 (-)



Homology
more
  • Human Ortholog
    MS4A1, membrane spanning 4-domains A1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MS4A1, membrane spanning 4-domains A1
  • Synonyms
    B1, Bp35, CD20, CVID5, FMC7, LEU-16, S7
  • Links
    NCBI Gene ID: 931
    neXtProt AC: NX_P11836
    UniProt: P11836

  • Chr Location
    11q12.2; chr11:60455846-60470752 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MS4A1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this locus affects B cell physiology but does not impair B cell development or overall immune function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    72
  • cDNA Data
    96
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12482 NCBI Gene Model | MGI Sequence Detail 16471 C57BL/6J ±  kb
transcript NM_007641 RefSeq | MGI Sequence Detail 2984 ZRU/MplStud  
polypeptide P19437 UniProt | EBI | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 98
    cDNA 96
    Primer pair 2

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-11986, MGD-MRK-1838, MGI:2147465
References
more
  • Summaries
    All 58
    Developmental Gene Expression 5
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:9496 Tedder TF, et al., Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19. J Immunol. 1988 Dec 15;141(12):4388-94
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory