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Cd8a Gene Detail
Summary
  • Symbol
    Cd8a
  • Name
    CD8 subunit alpha
  • Synonyms
    Ly-2, Ly-35, Ly-B, Lyt-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88346
    NCBI Gene: 12525
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:71350411-71356155 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 32.14 cM, cytoband C
  • Mapping Data
    67 experiments
Strain
Comparison
more
  • SNPs within 2kb
    228 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88346
 protein coding gene Chr6:71350411-71356157 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030857
 protein coding gene Chr6:71849732-71854529 (+)
A/J MGP_AJ_G0030827
 protein coding gene Chr6:69084573-69088632 (+)
AKR/J MGP_AKRJ_G0030756
 protein coding gene Chr6:71066698-71070779 (+)
BALB/cJ MGP_BALBcJ_G0030838
 protein coding gene Chr6:69116950-69121178 (+)
C3H/HeJ MGP_C3HHeJ_G0030874
 protein coding gene Chr6:113176288-113180358 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031296
 protein coding gene Chr6:73740391-73745169 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028485
 protein coding gene Chr6:68266010-68271500 (+)
CAST/EiJ MGP_CASTEiJ_G0029946
 protein coding gene Chr6:70930223-70936553 (+)
CBA/J MGP_CBAJ_G0030525
 protein coding gene Chr6:76666456-76676852 (+)
DBA/2J MGP_DBA2J_G0030677
 protein coding gene Chr6:68460370-68464455 (+)
FVB/NJ MGP_FVBNJ_G0030630
 protein coding gene Chr6:67826447-67830601 (+)
LP/J MGP_LPJ_G0030756
 protein coding gene Chr6:71775585-71779972 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030665
 protein coding gene Chr6:80157305-80161377 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031322
 protein coding gene Chr6:70914042-70918096 (+)
PWK/PhJ MGP_PWKPhJ_G0029662
 protein coding gene Chr6:67328964-67335237 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029490
 protein coding gene Chr6:69619207-69623244 (+)
WSB/EiJ MGP_WSBEiJ_G0030028
 protein coding gene Chr6:71252705-71257892 (+)



Homology
more
  • Human Ortholog
    CD8A, CD8 subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD8A, CD8 subunit alpha
  • Synonyms
    CD8, CD8alpha, IMD116, Leu2, p32
  • Links
    NCBI Gene ID: 925
    neXtProt AC: NX_P01732
    UniProt: P01732

  • Chr Location
    2p11.2; chr2:86784605-86808396 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CD8A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 7 alleles in 11 genetic backgrounds
    28 phenotypes from multigenic genotypes
    367 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation in this gene lack CD8+CD4- cytotoxic T cells in the thymus and spleen and do not mount a cytotoxic response to alloantigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    31
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    48
  • cDNA Data
    37
  • Literature Summary
    20
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12525 NCBI Gene Model | MGI Sequence Detail 5745 C57BL/6J ±  kb
transcript NM_001081110 RefSeq | MGI Sequence Detail 3130 Not Specified  
polypeptide P01731 UniProt | EBI | MGI Sequence Detail 247 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    Genomic 18
    cDNA 38
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11958, MGD-MRK-11976, MGD-MRK-12074, MGD-MRK-1872, MGI:2141733
References
more
  • Summaries
    All 632
    Developmental Gene Expression 20
    Gene Ontology 45
    Phenotypes 367
  • Earliest
    J:5073 Boyse EA, et al., Ly-A and Ly-B: two systems of lymphocyte isoantigens in the mouse. Proc R Soc Lond B Biol Sci. 1968 Jun 11;170(19):175-93
  • Latest
    J:354623 Ran L, et al., The transcription regulator ID3 maintains tumor-specific memory CD8(+) T cells in draining lymph nodes during tumorigenesis. Cell Rep. 2024 Sep 24;43(9):114690
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory