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Cdk1 Gene Detail
Summary
  • Symbol
    Cdk1
  • Name
    cyclin dependent kinase 1
  • Synonyms
    Cdc2, Cdc2a, p34CDC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88351
    NCBI Gene: 12534
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:69170976-69188742 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 36.07 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    761 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88351
 protein coding gene Chr10:69170976-69188768 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017334
 protein coding gene Chr10:69191908-69208202 (-)
A/J MGP_AJ_G0017311
 protein coding gene Chr10:66862288-66878941 (-)
AKR/J MGP_AKRJ_G0017272
 protein coding gene Chr10:68679507-68697190 (-)
BALB/cJ MGP_BALBcJ_G0017271
 protein coding gene Chr10:67053346-67069649 (-)
C3H/HeJ MGP_C3HHeJ_G0017095
 protein coding gene Chr10:68693304-68709607 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017729
 protein coding gene Chr10:71686965-71703268 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015419
 protein coding gene Chr10:63492585-63509220 (-)
CAST/EiJ MGP_CASTEiJ_G0016665
 protein coding gene Chr10:68781517-68799380 (-)
CBA/J MGP_CBAJ_G0017067
 protein coding gene Chr10:74438177-74455369 (-)
DBA/2J MGP_DBA2J_G0017172
 protein coding gene Chr10:66220255-66236528 (-)
FVB/NJ MGP_FVBNJ_G0017165
 protein coding gene Chr10:65386127-65402837 (-)
LP/J MGP_LPJ_G0017245
 protein coding gene Chr10:69620933-69637235 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017193
 protein coding gene Chr10:76609272-76625569 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017768
 protein coding gene Chr10:68605189-68623861 (-)
PWK/PhJ MGP_PWKPhJ_G0016449
 protein coding gene Chr10:66034505-66070420 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016231
 protein coding gene Chr10:67964423-67981650 (-)
WSB/EiJ MGP_WSBEiJ_G0016729
 protein coding gene Chr10:68535579-68553854 (-)



Homology
more
  • Human Ortholog
    CDK1, cyclin dependent kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK1, cyclin dependent kinase 1
  • Synonyms
    CDC2, CDC28A, P34CDC2
  • Links
    NCBI Gene ID: 983
    neXtProt AC: NX_P06493
    UniProt: P06493

  • Chr Location
    10q21.2; chr10:60778331-60794852 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human CDK1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 7 alleles in 9 genetic backgrounds
    20 phenotypes from multigenic genotypes
    3 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele die prior to E1.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    131
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    134
  • cDNA Data
    145
  • Literature Summary
    75
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12534 NCBI Gene Model | MGI Sequence Detail 17767 C57BL/6J ±  kb
    transcript NM_007659 RefSeq | MGI Sequence Detail 4362 ZRU/MplStud  
    polypeptide P11440 UniProt | EBI | MGI Sequence Detail 297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 155
      cDNA 145
      Primer pair 6
      Other 4

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1878
    References
    more
    • Summaries
      All 220
      Developmental Gene Expression 75
      Gene Ontology 26
      Phenotypes 42
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:355487 Han Z, et al., The subcortical maternal complex modulates the cell cycle during early mammalian embryogenesis via 14-3-3. Nat Commun. 2024 Oct 15;15(1):8887
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory