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Cdx2 Gene Detail
Summary
  • Symbol
    Cdx2
  • Name
    caudal type homeobox 2
  • Synonyms
    Cdx-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:88361
    NCBI Gene: 12591
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147237710-147244059 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 86.86 cM, cytoband G2-G3
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    155 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88361
 protein coding gene Chr5:147237615-147244080 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030387
 protein coding gene Chr5:152943944-152950409 (-)
A/J MGP_AJ_G0030360
 protein coding gene Chr5:146468996-146475974 (-)
AKR/J MGP_AKRJ_G0030287
 protein coding gene Chr5:150972492-150978957 (-)
BALB/cJ MGP_BALBcJ_G0030369
 protein coding gene Chr5:147681548-147688013 (-)
C3H/HeJ MGP_C3HHeJ_G0030083
 protein coding gene Chr5:151935675-151942140 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030824
 protein coding gene Chr5:158546665-158553130 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028037
 protein coding gene Chr5:140885620-140892072 (-)
CAST/EiJ MGP_CASTEiJ_G0029485
 protein coding gene Chr5:151491887-151498358 (-)
CBA/J MGP_CBAJ_G0030061
 protein coding gene Chr5:165156705-165163170 (-)
DBA/2J MGP_DBA2J_G0030205
 protein coding gene Chr5:146153119-146159585 (-)
FVB/NJ MGP_FVBNJ_G0030159
 protein coding gene Chr5:145349587-145356052 (-)
LP/J MGP_LPJ_G0030292
 protein coding gene Chr5:153645969-153652434 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030195
 protein coding gene Chr5:167434255-167440720 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030854
 protein coding gene Chr5:150876110-150882577 (-)
PWK/PhJ MGP_PWKPhJ_G0029199
 protein coding gene Chr5:145235833-145242297 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029035
 protein coding gene Chr5:148198801-148205287 (-)
WSB/EiJ MGP_WSBEiJ_G0029562
 protein coding gene Chr5:151679184-151685650 (-)



Homology
more
  • Human Ortholog
    CDX2, caudal type homeobox 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDX2, caudal type homeobox 2
  • Synonyms
    CDX2/AS, CDX-3, CDX3
  • Links
    NCBI Gene ID: 1045
    neXtProt AC: NX_Q99626
    UniProt: Q99626

  • Chr Location
    13q12.2; chr13:27960918-27969315 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 9 alleles in 15 genetic backgrounds
    22 phenotypes from multigenic genotypes
    85 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die prior to gastrulation. Heterozygotes exhibit tail abnormalities, stunted growth, defects of the vertebrae and ribs, and multiple intestinal adenomatous polyps.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1564
  • Tissues
    227
  • cDNA Data
    20
  • Literature Summary
    322
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12591 NCBI Gene Model | MGI Sequence Detail 6350 C57BL/6J ±  kb
    transcript NM_007673 RefSeq | MGI Sequence Detail 2145 ZRU/MplStud  
    polypeptide P43241 UniProt | EBI | MGI Sequence Detail 311 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      Genomic 3
      cDNA 22
      Primer pair 27
      Other 17

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1890, MGD-MRK-1894
    References
    more
    • Summaries
      All 468
      Developmental Gene Expression 322
      Gene Ontology 30
      Phenotypes 85
    • Earliest
      J:10984 James R, et al., Homeobox gene expression in the intestinal epithelium of adult mice. J Biol Chem. 1991 Feb 15;266(5):3246-51
    • Latest
      J:355696 Chen S, et al., Terminal alpha1,2-fucosylation of glycosphingolipids by FUT1 is a key regulator in early cell-fate decisions. EMBO Rep. 2024 Oct;25(10):4433-4464
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory