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F3 Gene Detail
Summary
  • Symbol
    F3
  • Name
    coagulation factor III
  • Synonyms
    CD142, Cf-3, Cf3, TF, tissue factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:88381
    NCBI Gene: 14066
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:121517186-121528697 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 52.94 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    445 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88381
 protein coding gene Chr3:121517186-121528701 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027833
 protein coding gene Chr3:123928552-123942627 (+)
A/J MGP_AJ_G0027791
 protein coding gene Chr3:119799037-119810535 (+)
AKR/J MGP_AKRJ_G0027757
 protein coding gene Chr3:122850352-122861878 (+)
BALB/cJ MGP_BALBcJ_G0027803
 protein coding gene Chr3:119615718-119627313 (+)
C3H/HeJ MGP_C3HHeJ_G0027534
 protein coding gene Chr3:123243303-123254812 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028249
 protein coding gene Chr3:128415685-128427291 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025588
 protein coding gene Chr3:115230476-115241190 (+)
CAST/EiJ MGP_CASTEiJ_G0026990
 protein coding gene Chr3:122620636-122633742 (+)
CBA/J MGP_CBAJ_G0027509
 protein coding gene Chr3:132763238-132779415 (+)
DBA/2J MGP_DBA2J_G0027650
 protein coding gene Chr3:118953079-118964338 (+)
FVB/NJ MGP_FVBNJ_G0027618
 protein coding gene Chr3:116560382-116572367 (+)
LP/J MGP_LPJ_G0027760
 protein coding gene Chr3:125457515-125469459 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027648
 protein coding gene Chr3:140384556-140396416 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028305
 protein coding gene Chr3:122403365-122414870 (+)
PWK/PhJ MGP_PWKPhJ_G0026716
 protein coding gene Chr3:118650059-118661677 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026539
 protein coding gene Chr3:120483065-120494088 (+)
WSB/EiJ MGP_WSBEiJ_G0027070
 protein coding gene Chr3:123125644-123144257 (+)



Homology
more
  • Human Ortholog
    F3, coagulation factor III, tissue factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    F3, coagulation factor III, tissue factor
  • Synonyms
    CD142, TF, TFA
  • Links
    NCBI Gene ID: 2152
    neXtProt AC: NX_P13726
    UniProt: P13726

  • Chr Location
    1p21.3; chr1:94529173-94541759 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human F3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 7 alleles in 10 genetic backgrounds
    18 phenotypes from multigenic genotypes
    1 images
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired blood vessel development, retarded growth, and, in most cases, midgestational lethality. On a mixed background, some mutants survive to birth and appear to be normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    988
  • Tissues
    103
  • cDNA Data
    52
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028128 Ensembl Gene Model | MGI Sequence Detail 11512 C57BL/6J ±  kb
    transcript ENSMUST00000029771 Ensembl | MGI Sequence Detail 1872 Not Applicable  
    polypeptide ENSMUSP00000029771 Ensembl | MGI Sequence Detail 294 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 1
      cDNA 52
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1947, MGD-MRK-1953, MGI:2139567
    References
    more
    • Summaries
      All 164
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 5
      Phenotypes 86
    • Earliest
      J:9927 Hartzell S, et al., A growth factor-responsive gene of murine BALB/c 3T3 cells encodes a protein homologous to human tissue factor. Mol Cell Biol. 1989 Jun;9(6):2567-73
    • Latest
      J:354028 Ballard-Kordeliski A, et al., 4D intravital imaging studies identify platelets as the predominant cellular procoagulant surface in a mouse hemostasis model. Blood. 2024 Sep 5;144(10):1116-1126
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory