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Ckb Gene Detail
Summary
  • Symbol
    Ckb
  • Name
    creatine kinase, brain
  • Synonyms
    B-CK, Ck-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:88407
    NCBI Gene: 12709
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:111635795-111638772 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 61.09 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    112 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88407
 protein coding gene Chr12:111635789-111638772 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020137
 protein coding gene Chr12:114070940-114073922 (-)
A/J MGP_AJ_G0020093
 protein coding gene Chr12:109691731-109694713 (-)
AKR/J MGP_AKRJ_G0020068
 protein coding gene Chr12:112827751-112830733 (-)
BALB/cJ MGP_BALBcJ_G0020078
 protein coding gene Chr12:110115560-110118538 (-)
C3H/HeJ MGP_C3HHeJ_G0019880
 protein coding gene Chr12:113331004-113333986 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020523
 protein coding gene Chr12:117613816-117616786 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018136
 protein coding gene Chr12:106131221-106134201 (-)
CAST/EiJ MGP_CASTEiJ_G0019421
 protein coding gene Chr12:108170328-108173318 (-)
CBA/J MGP_CBAJ_G0019847
 protein coding gene Chr12:122084223-122087205 (-)
DBA/2J MGP_DBA2J_G0019964
 protein coding gene Chr12:109167108-109170090 (-)
FVB/NJ MGP_FVBNJ_G0019949
 protein coding gene Chr12:107968168-107972052 (-)
LP/J MGP_LPJ_G0020039
 protein coding gene Chr12:113897555-113900548 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019987
 protein coding gene Chr12:125221108-125224901 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020552
 protein coding gene Chr12:112350701-112353694 (-)
PWK/PhJ MGP_PWKPhJ_G0019182
 protein coding gene Chr12:103812671-103815654 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018985
 protein coding gene Chr12:106519896-106522869 (-)
WSB/EiJ MGP_WSBEiJ_G0019480
 protein coding gene Chr12:113259830-113262812 (-)



Homology
more
  • Human Ortholog
    CKB, creatine kinase B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CKB, creatine kinase B
  • Synonyms
    B-CK, BCK, CKBB, CPK-B, HEL-211, HEL-S-29
  • Links
    NCBI Gene ID: 1152
    neXtProt AC: NX_P12277
    UniProt: P12277

  • Chr Location
    14q32.33; chr14:103519667-103522833 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice have abnormal hippocampal morphology with enlarged mossy fiber field size and display resistance to pharmacologically induced seizures, reduced habituation and spatial learning impairments.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1329
  • Tissues
    206
  • cDNA Data
    20
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001270 Ensembl Gene Model | MGI Sequence Detail 2978 C57BL/6J ±  kb
    transcript ENSMUST00000001304 Ensembl | MGI Sequence Detail 1472 Not Applicable  
    polypeptide ENSMUSP00000001304 Ensembl | MGI Sequence Detail 381 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005513 creatine kinase B-type
      (term hierarchy)
    • EC
      2.7.3.2
    • InterPro Domains
      IPR000749 ATP:guanido phosphotransferase
      IPR022415 ATP:guanido phosphotransferase active site
      IPR022414 ATP:guanido phosphotransferase, catalytic domain
      IPR022413 ATP:guanido phosphotransferase, N-terminal
      IPR036802 ATP:guanido phosphotransferase, N-terminal domain superfamily
      IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
    • GlyGen
      Q04447 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 34
      Genomic 4
      cDNA 22
      Primer pair 6
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-1990, MGD-MRK-1997
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 23
    • Earliest
      J:455 Cho M, et al., A linkage map of distal mouse chromosome 12. Mamm Genome. 1991;1(1):30-6
    • Latest
      J:349007 Eberhard CD, et al., Tenofovir Activation Is Diminished in the Brain and Liver of Creatine Kinase Brain-Type Knockout Mice. ACS Pharmacol Transl Sci. 2024 Jan 12;7(1):222-235
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory