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Ctsg Gene Detail
Summary
  • Symbol
    Ctsg
  • Name
    cathepsin G
  • Feature Type
    protein coding gene
  • IDs
    MGI:88563
    NCBI Gene: 13035
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56337342-56340031 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88563
 protein coding gene Chr14:56337338-56340031 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021384
 protein coding gene Chr14:50175285-50177978 (-)
A/J MGP_AJ_G0021343
 protein coding gene Chr14:49179634-49182327 (-)
AKR/J MGP_AKRJ_G0021319
 protein coding gene Chr14:50936350-50939043 (-)
BALB/cJ MGP_BALBcJ_G0021346
 protein coding gene Chr14:49149837-49152530 (-)
C3H/HeJ MGP_C3HHeJ_G0021127
 protein coding gene Chr14:50619798-50622491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021786
 protein coding gene Chr14:52698088-52700781 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019328
 protein coding gene Chr14:47393134-47395789 (-)
CAST/EiJ MGP_CASTEiJ_G0020646
 protein coding gene Chr14:46903200-46905826 (-)
CBA/J MGP_CBAJ_G0021094
 protein coding gene Chr14:54241282-54243975 (-)
DBA/2J MGP_DBA2J_G0021214
 protein coding gene Chr14:48902457-48905118 (-)
FVB/NJ MGP_FVBNJ_G0021197
 protein coding gene Chr14:48317944-48320636 (-)
LP/J MGP_LPJ_G0021289
 protein coding gene Chr14:51217915-51220608 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021221
 protein coding gene Chr14:53602339-53605031 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021812
 protein coding gene Chr14:50122910-50125603 (-)
PWK/PhJ MGP_PWKPhJ_G0020390
 protein coding gene Chr14:45425859-45428552 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020220
 protein coding gene Chr14:46179501-46182188 (-)
WSB/EiJ MGP_WSBEiJ_G0020699
 protein coding gene Chr14:50379956-50382648 (-)



Homology
more
  • Human Ortholog
    CTSG, cathepsin G
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSG, cathepsin G
  • Synonyms
    CATG, CG
  • Links
    NCBI Gene ID: 1511
    neXtProt AC: NX_P08311
    UniProt: P08311

  • Chr Location
    14q12; chr14:24573518-24576250 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotypes from multigenic genotypes
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygous for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    62
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    1
  • cDNA Data
    16
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13035 NCBI Gene Model | MGI Sequence Detail 2690 C57BL/6J ±  kb
transcript NM_007800 RefSeq | MGI Sequence Detail 1015 ZRU/MplStud  
polypeptide P28293 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    Genomic 7
    cDNA 16
    Other 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-2247
References
more
  • Summaries
    All 84
    Developmental Gene Expression 2
    Diseases 2
    Gene Ontology 10
    Phenotypes 49
  • Earliest
    J:9920 Hohn PA, et al., Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15;264(23):13412-9
  • Latest
    J:341196 Yang WH, et al., Innate mechanism of mucosal barrier erosion in the pathogenesis of acquired colitis. iScience. 2023 Oct 20;26(10):107883
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory