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Ctsl Gene Detail
Summary
  • Symbol
    Ctsl
  • Name
    cathepsin L
  • Synonyms
    1190035F06Rik, Cat L, major excreted protein, MEP
  • Feature Type
    protein coding gene
  • IDs
    MGI:88564
    NCBI Gene: 13039
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:64509704-64518586 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 33.26 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    383 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88564
 protein coding gene Chr13:64507151-64518704 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020678
 protein coding gene Chr13:64387134-64394038 (-)
A/J MGP_AJ_G0020632
 protein coding gene Chr13:62053494-62060549 (-)
AKR/J MGP_AKRJ_G0020609
 protein coding gene Chr13:64105659-64112535 (-)
BALB/cJ MGP_BALBcJ_G0020630
 protein coding gene Chr13:62479527-62486895 (-)
C3H/HeJ MGP_C3HHeJ_G0020425
 protein coding gene Chr13:63629609-63636588 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021066
 protein coding gene Chr13:66459209-66466354 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018642
 protein coding gene Chr13:59704820-59711635 (-)
CAST/EiJ MGP_CASTEiJ_G0019942
 protein coding gene Chr13:63647741-63654846 (-)
CBA/J MGP_CBAJ_G0020385
 protein coding gene Chr13:69014086-69020981 (-)
DBA/2J MGP_DBA2J_G0020510
 protein coding gene Chr13:61882642-61889545 (-)
FVB/NJ MGP_FVBNJ_G0020489
 protein coding gene Chr13:60982828-60989760 (-)
LP/J MGP_LPJ_G0020584
 protein coding gene Chr13:64668240-64675201 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020518
 protein coding gene Chr13:67955764-67962774 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021108
 protein coding gene Chr13:63424351-63431357 (-)
PWK/PhJ MGP_PWKPhJ_G0019696
 protein coding gene Chr13:61448331-61455686 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019522
 protein coding gene Chr13:61588932-61595997 (-)
WSB/EiJ MGP_WSBEiJ_G0020002
 protein coding gene Chr13:63899953-63907705 (-)



Homology
more
  • Human Ortholog
    CTSL, cathepsin L
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSL, cathepsin L
  • Synonyms
    CATL, CTSL1, MEP
  • Links
    NCBI Gene ID: 1514
    neXtProt AC: NX_P07711
    UniProt: P07711

  • Chr Location
    9q21.33; chr9:87724051-87731469 (+)  GRCh38
  • Human Ortholog
    CTSV, cathepsin V
  • Synonyms
    CATL2, CTSL2, CTSU
  • Links
    NCBI Gene ID: 1515
    neXtProt AC: NX_O60911
    UniProt: O60911

  • Chr Location
    9q22.33; chr9:97029677-97156556 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ctsl mouse models; 1 with human CTSL associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    117 phenotypes from 7 alleles in 12 genetic backgrounds
    17 phenotypes from multigenic genotypes
    6 images
    108 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for mutant alleles may show partial or complete hair-loss, skin defects, impaired T cell maturation, dilated cardiomyopathy, and high postnatal mortality. Mutant males for some alleles show both normal and atrophic seminiferous tubules and reduced sperm production.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    87
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    938
  • Tissues
    161
  • cDNA Data
    867
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13039 NCBI Gene Model | MGI Sequence Detail 8883 C57BL/6J ±  kb
    transcript NM_001428552 RefSeq | MGI Sequence Detail 1409 C57BL/6  
    polypeptide P06797 UniProt | EBI | MGI Sequence Detail 334 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 874
      cDNA 868
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2248, MGD-MRK-9874, MGI:1338075, MGI:2443888, MGI:95581
    References
    more
    • Summaries
      All 203
      Developmental Gene Expression 24
      Diseases 1
      Gene Ontology 24
      Phenotypes 108
    • Earliest
      J:15332 Green EL, The genetics of a new hair deficiency, furless, in the house mouse. J Hered. 1954;45(3):115-18
    • Latest
      J:346626 Kim MJ, et al., Inhibition of cysteine protease cathepsin Lincreases the level and activity of lysosomal glucocerebrosidase. JCI Insight. 2024 Feb 8;9(3)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory