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Cycs Gene Detail
Summary
  • Symbol
    Cycs
  • Name
    cytochrome c, somatic
  • Feature Type
    protein coding gene
  • IDs
    MGI:88578
    NCBI Gene: 13063
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:50539543-50543518 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 24.32 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_88578
 protein coding gene Chr6:50539543-50543549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030730
 protein coding gene Chr6:49680640-49687724 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0030626
 protein coding gene Chr6:49022771-49032843 (-)
BALB/cJ MGP_BALBcJ_G0030711
 protein coding gene Chr6:47709990-47713561 (-)
C3H/HeJ MGP_C3HHeJ_G0030424
 protein coding gene Chr6:49051274-49055249 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031166
 protein coding gene Chr6:50797921-50801229 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028373
 protein coding gene Chr6:44970428-44974642 (-)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0030548
 protein coding gene Chr6:47277603-47282533 (-)
FVB/NJ MGP_FVBNJ_G0030500
 protein coding gene Chr6:46915758-46919765 (-)
LP/J MGP_LPJ_G0030633
 protein coding gene Chr6:49640382-49644355 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030534
 protein coding gene Chr6:55646536-55652007 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031195
 protein coding gene Chr6:48947734-48951813 (-)
PWK/PhJ MGP_PWKPhJ_G0029540
 protein coding gene Chr6:46854251-46858109 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CYCS, cytochrome c, somatic
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CYCS, cytochrome c, somatic
  • Synonyms
    CYC, HCS, THC4
  • Links
    NCBI Gene ID: 54205
    neXtProt AC: NX_P99999
    UniProt: P99999

  • Chr Location
    7p15.3; chr7:25118656-25125260 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CYCS associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die at midgestation. By E8.5, homozygous null embryos exhibit a strikingly reduced size and are developmentally retarded.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    887
  • Tissues
    51
  • cDNA Data
    230
  • Literature Summary
    26
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063694 Ensembl Gene Model | MGI Sequence Detail 3976 C57BL/6J ±  kb
    transcript ENSMUST00000161401 Ensembl | MGI Sequence Detail 3123 Not Applicable  
    polypeptide ENSMUSP00000124523 Ensembl | MGI Sequence Detail 105 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 234
      Genomic 2
      cDNA 230
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-2287
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 26
      Gene Ontology 21
      Phenotypes 13
    • Earliest
      J:38101 Limbach KJ, et al., Characterization of a mouse somatic cytochrome c gene and three cytochrome c pseudogenes. Nucleic Acids Res. 1985 Jan 25;13(2):617-30
    • Latest
      J:332399 Sato K, et al., Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes. Biochem Biophys Res Commun. 2023 Jan 1;638:168-175
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory