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Sfrp1 Gene Detail
Summary
  • Symbol
    Sfrp1
  • Name
    secreted frizzled-related protein 1
  • Synonyms
    2210415K03Rik, sFRP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:892014
    NCBI Gene: 20377
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:23901518-23939648 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.48 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1097 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_892014
 protein coding gene Chr8:23901401-23939648 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033466
 protein coding gene Chr8:21335310-21374813 (+)
A/J MGP_AJ_G0033446
 protein coding gene Chr8:20611109-20649151 (+)
AKR/J MGP_AKRJ_G0033371
 protein coding gene Chr8:21290955-21333009 (+)
BALB/cJ MGP_BALBcJ_G0033442
 protein coding gene Chr8:20737001-20775755 (+)
C3H/HeJ MGP_C3HHeJ_G0033156
 protein coding gene Chr8:21494224-21533377 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033958
 protein coding gene Chr8:22202774-22244822 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030908
 protein coding gene Chr8:17935006-17973327 (+)
CAST/EiJ MGP_CASTEiJ_G0032482
 protein coding gene Chr8:20915967-20986855 (+)
CBA/J MGP_CBAJ_G0033131
 protein coding gene Chr8:23093342-23133586 (+)
DBA/2J MGP_DBA2J_G0033286
 protein coding gene Chr8:20586193-20625470 (+)
FVB/NJ MGP_FVBNJ_G0033230
 protein coding gene Chr8:20382120-20420300 (+)
LP/J MGP_LPJ_G0033375
 protein coding gene Chr8:21323138-21361990 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033273
 protein coding gene Chr8:22643855-22682893 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033977
 protein coding gene Chr8:21210527-21248536 (+)
PWK/PhJ MGP_PWKPhJ_G0032193
 protein coding gene Chr8:20182104-20252444 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032027
 protein coding gene Chr8:20561381-20599310 (+)
WSB/EiJ MGP_WSBEiJ_G0032598
 protein coding gene Chr8:21409397-21450821 (+)



Homology
more
  • Human Ortholog
    SFRP1, secreted frizzled related protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SFRP1, secreted frizzled related protein 1
  • Synonyms
    FRP, FRP-1, FRP1, FrzA, SARP2
  • Links
    NCBI Gene ID: 6422
    neXtProt AC: NX_Q8N474
    UniProt: Q8N474

  • Chr Location
    8p11.21; chr8:41261962-41309473 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotypes from multigenic genotypes
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display increased trabecular bone area, decreased brain weights, slight hematological abnormalities in males, and increased heart weight in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    158
  • GO References
    28
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1387
  • Tissues
    430
  • cDNA Data
    171
  • Literature Summary
    121
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031548 Ensembl Gene Model | MGI Sequence Detail 38131 C57BL/6J ±  kb
    transcript ENSMUST00000033952 Ensembl | MGI Sequence Detail 4372 Not Applicable  
    polypeptide ENSMUSP00000033952 Ensembl | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 197
      cDNA 175
      Primer pair 16
      Other 6

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1919612, MGI:2142743, MGI:2142757, MGI:2142814
    References
    more
    • Summaries
      All 194
      Developmental Gene Expression 121
      Gene Ontology 28
      Phenotypes 42
    • Earliest
      J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
    • Latest
      J:348279 Wrynn T, et al., DeltaNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis. PLoS One. 2024;19(5):e0301082
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory