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Ebf2 Gene Detail
Summary
  • Symbol
    Ebf2
  • Name
    early B cell factor 2
  • Synonyms
    D14Ggc1e, Mmot1, O/E-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:894332
    NCBI Gene: 13592
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:67470741-67668367 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 34.63 cM, cytoband D-E1
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4575 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894332
 protein coding gene Chr14:67470741-67668401 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021503
 protein coding gene Chr14:61954848-62158953 (+)
A/J MGP_AJ_G0021462
 protein coding gene Chr14:60465053-60667868 (+)
AKR/J MGP_AKRJ_G0021438
 protein coding gene Chr14:62539380-62742553 (+)
BALB/cJ MGP_BALBcJ_G0021468
 protein coding gene Chr14:60461370-60663282 (+)
C3H/HeJ MGP_C3HHeJ_G0021245
 protein coding gene Chr14:62265658-62466083 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021907
 protein coding gene Chr14:64775925-64989960 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019447
 protein coding gene Chr14:58375521-58576239 (+)
CAST/EiJ MGP_CASTEiJ_G0020762
 protein coding gene Chr14:58745846-58957961 (+)
CBA/J MGP_CBAJ_G0021212
 protein coding gene Chr14:66762626-66980907 (+)
DBA/2J MGP_DBA2J_G0021335
 protein coding gene Chr14:60104561-60304715 (+)
FVB/NJ MGP_FVBNJ_G0021314
 protein coding gene Chr14:59509878-59710563 (+)
LP/J MGP_LPJ_G0021410
 protein coding gene Chr14:63012957-63218440 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021343
 protein coding gene Chr14:65765231-65976986 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021930
 protein coding gene Chr14:61765004-61972440 (+)
PWK/PhJ MGP_PWKPhJ_G0020506
 protein coding gene Chr14:56856778-57060059 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020339
 protein coding gene Chr14:57734005-57934898 (+)
WSB/EiJ MGP_WSBEiJ_G0020815
 protein coding gene Chr14:62086498-62295621 (+)



Homology
more
  • Human Ortholog
    EBF2, EBF transcription factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EBF2, EBF transcription factor 2
  • Synonyms
    COE2, EBF-2, O/E-3, OE-3
  • Links
    NCBI Gene ID: 64641
    neXtProt AC: NX_Q9HAK2
    UniProt: Q9HAK2

  • Chr Location
    8p21.2; chr8:25841725-26045413 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    70 phenotypes from 9 alleles in 10 genetic backgrounds
    4 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants show decreased viability, impaired olfactory neuron projection, and impaired mating, more so in male mice. Mice homozygous for another knock-out allele exhibit narcolepsy-cataplexy syndrome and decreased orexinergic neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1080
  • Tissues
    260
  • cDNA Data
    47
  • Literature Summary
    69
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022053 Ensembl Gene Model | MGI Sequence Detail 197627 C57BL/6J ±  kb
    transcript ENSMUST00000022637 Ensembl | MGI Sequence Detail 4352 Not Applicable  
    polypeptide ENSMUSP00000022637 Ensembl | MGI Sequence Detail 575 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 57
      cDNA 48
      Primer pair 6
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-34015, MGI:106323, MGI:894328
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 69
      Gene Ontology 7
      Phenotypes 31
    • Earliest
      J:37805 Cornwall GA, et al., ADAM7, a member of the ADAM (a disintegrin and metalloprotease) gene family is specifically expressed in the mouse anterior pituitary and epididymis. Endocrinology. 1997 Oct;138(10):4262-72
    • Latest
      J:354191 Kc R, et al., Multimodal Hox5 activity generates motor neuron diversity. Commun Biol. 2024 Sep 17;7(1):1166
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory