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Galnt3 Gene Detail
Summary
  • Symbol
    Galnt3
  • Name
    polypeptide N-acetylgalactosaminyltransferase 3
  • Synonyms
    ppGaNTase-T3
  • Feature Type
    protein coding gene
  • IDs
    MGI:894695
    NCBI Gene: 14425
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:65913110-65955217 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 38.99 cM, cytoband C3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1257 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894695
 protein coding gene Chr2:65913110-65955338 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025782
 protein coding gene Chr2:65918703-65962652 (-)
A/J MGP_AJ_G0025758
 protein coding gene Chr2:63357994-63401531 (-)
AKR/J MGP_AKRJ_G0025728
 protein coding gene Chr2:65079307-65122236 (-)
BALB/cJ MGP_BALBcJ_G0025753
 protein coding gene Chr2:63530519-63572718 (-)
C3H/HeJ MGP_C3HHeJ_G0025514
 protein coding gene Chr2:65268311-65311539 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026200
 protein coding gene Chr2:67855175-67902810 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023604
 protein coding gene Chr2:60704503-60747560 (-)
CAST/EiJ MGP_CASTEiJ_G0024978
 protein coding gene Chr2:65305435-65355455 (-)
CBA/J MGP_CBAJ_G0025494
 protein coding gene Chr2:70385310-70429454 (-)
DBA/2J MGP_DBA2J_G0025625
 protein coding gene Chr2:62991415-63034148 (-)
FVB/NJ MGP_FVBNJ_G0025587
 protein coding gene Chr2:62423335-62466291 (-)
LP/J MGP_LPJ_G0025713
 protein coding gene Chr2:65745601-65791931 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025618
 protein coding gene Chr2:72358504-72405859 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026257
 protein coding gene Chr2:65143234-65190278 (-)
PWK/PhJ MGP_PWKPhJ_G0024719
 protein coding gene Chr2:62818394-62861050 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024526
 protein coding gene Chr2:65297004-65343825 (-)
WSB/EiJ MGP_WSBEiJ_G0025046
 protein coding gene Chr2:65511620-65556897 (-)



Homology
more
  • Human Ortholog
    GALNT3, polypeptide N-acetylgalactosaminyltransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GALNT3, polypeptide N-acetylgalactosaminyltransferase 3
  • Synonyms
    GalNAc-T3, HFTC, HFTC1, HHS
  • Links
    NCBI Gene ID: 2591
    neXtProt AC: NX_Q14435
    UniProt: Q14435

  • Chr Location
    2q24.3; chr2:165747588-165846201 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Galnt3 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    46 phenotypes from 4 alleles in 4 genetic backgrounds
    2 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele show low serum FGF23 levels, hyperphosphatemia, normal 1,25-dihydroxyvitamin D levels, and male-specific growth retardation, sterility and increased bone density. Males homozygous for another null allele show abnormal acrosome assembly and oligoasthenoteratozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    115
  • cDNA Data
    76
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14425 NCBI Gene Model | MGI Sequence Detail 42108 C57BL/6J ±  kb
    transcript NM_015736 RefSeq | MGI Sequence Detail 3650 C57BL/6  
    polypeptide P70419 UniProt | EBI | MGI Sequence Detail 633 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 76
      Primer pair 6
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 7
      Diseases 2
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:36626 Zara J, et al., Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3. Biochem Biophys Res Commun. 1996 Nov 1;228(1):38-44
    • Latest
      J:299981 Clerin V, et al., Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion. J Clin Invest. 2020 Dec 1;130(12):6510-6522
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory