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Serping1 Gene Detail
Summary
  • Symbol
    Serping1
  • Name
    serine (or cysteine) peptidase inhibitor, clade G, member 1
  • Synonyms
    C1INH, C1 inhibitor, C1nh
  • Feature Type
    protein coding gene
  • IDs
    MGI:894696
    NCBI Gene: 12258
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84595704-84605748 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894696
 protein coding gene Chr2:84595704-84605788 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025910
 protein coding gene Chr2:85455494-85465401 (-)
A/J MGP_AJ_G0025884
 protein coding gene Chr2:82151028-82160877 (-)
AKR/J MGP_AKRJ_G0025854
 protein coding gene Chr2:84268351-84280032 (-)
BALB/cJ MGP_BALBcJ_G0025881
 protein coding gene Chr2:82284257-82294274 (-)
C3H/HeJ MGP_C3HHeJ_G0025640
 protein coding gene Chr2:84511582-84523404 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026327
 protein coding gene Chr2:88103439-88114381 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023729
 protein coding gene Chr2:78976910-78986912 (-)
CAST/EiJ MGP_CASTEiJ_G0025101
 protein coding gene Chr2:85041066-85052585 (-)
CBA/J MGP_CBAJ_G0025621
 protein coding gene Chr2:91254185-91266535 (-)
DBA/2J MGP_DBA2J_G0025752
 protein coding gene Chr2:81689507-81699376 (-)
FVB/NJ MGP_FVBNJ_G0025715
 protein coding gene Chr2:80945646-80956754 (-)
LP/J MGP_LPJ_G0025840
 protein coding gene Chr2:85253508-85265172 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025745
 protein coding gene Chr2:93574759-93586353 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026383
 protein coding gene Chr2:84505673-84521639 (-)
PWK/PhJ MGP_PWKPhJ_G0024845
 protein coding gene Chr2:81531251-81541611 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024649
 protein coding gene Chr2:84644646-84654496 (-)
WSB/EiJ MGP_WSBEiJ_G0025171
 protein coding gene Chr2:85173216-85183949 (-)



Homology
more
  • Human Ortholog
    SERPING1, serpin family G member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SERPING1, serpin family G member 1
  • Synonyms
    C1IN, C1INH, C1NH, HAE1, HAE2
  • Links
    NCBI Gene ID: 710
    neXtProt AC: NX_P05155
    UniProt: P05155

  • Chr Location
    11q12.1; chr11:57597387-57619171 (+)  GRCh38
Human Diseases
more
  • Diseases
    8 with human SERPING1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutant mice exhibit an increased vascular permeability compared to controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    729
  • Tissues
    21
  • cDNA Data
    254
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12258 NCBI Gene Model | MGI Sequence Detail 10045 C57BL/6J ±  kb
    transcript NM_001420027 RefSeq | MGI Sequence Detail 1800 C57BL/6  
    polypeptide P97290 UniProt | EBI | MGI Sequence Detail 504 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 258
      Genomic 2
      cDNA 254
      Primer pair 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 63
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 22
    • Earliest
      J:40775 Russell JA, et al., The sequence of a cDNA encoding functional murine C1-inhibitor protein. Biochim Biophys Acta. 1997 May 30;1352(2):156-60
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory