About   Help   FAQ
Ldb1 Gene Detail
Summary
  • Symbol
    Ldb1
  • Name
    LIM domain binding 1
  • Synonyms
    CLIM2
  • Feature Type
    protein coding gene
  • IDs
    MGI:894762
    NCBI Gene: 16825
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:46020009-46033653 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 38.75 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    343 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_894762
 protein coding gene Chr19:46019963-46036584 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025197
 protein coding gene Chr19:45689226-45703885 (-)
A/J MGP_AJ_G0025173
 protein coding gene Chr19:43442953-43457748 (-)
AKR/J MGP_AKRJ_G0025142
 protein coding gene Chr19:44850150-44862798 (-)
BALB/cJ MGP_BALBcJ_G0025168
 protein coding gene Chr19:43499714-43513636 (-)
C3H/HeJ MGP_C3HHeJ_G0024928
 protein coding gene Chr19:45022667-45036348 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025611
 protein coding gene Chr19:46827735-46841077 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023025
 protein coding gene Chr19:42681003-42693853 (-)
CAST/EiJ MGP_CASTEiJ_G0024393
 protein coding gene Chr19:44793667-44806311 (-)
CBA/J MGP_CBAJ_G0024908
 protein coding gene Chr19:49185241-49198514 (-)
DBA/2J MGP_DBA2J_G0025040
 protein coding gene Chr19:43262270-43275970 (-)
FVB/NJ MGP_FVBNJ_G0025001
 protein coding gene Chr19:43038602-43051879 (-)
LP/J MGP_LPJ_G0025126
 protein coding gene Chr19:45599403-45613361 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025032
 protein coding gene Chr19:48545324-48560474 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025669
 protein coding gene Chr19:44955528-44970749 (-)
PWK/PhJ MGP_PWKPhJ_G0024142
 protein coding gene Chr19:43192901-43206759 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023946
 protein coding gene Chr19:43613533-43626348 (-)
WSB/EiJ MGP_WSBEiJ_G0024463
 protein coding gene Chr19:45099904-45115910 (-)



Homology
more
  • Human Ortholog
    LDB1, LIM domain binding 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LDB1, LIM domain binding 1
  • Synonyms
    CLIM-2, CLIM2, LDB-1, NLI
  • Links
    NCBI Gene ID: 8861
    neXtProt AC: NX_Q86U70
    UniProt: Q86U70

  • Chr Location
    10q24.32; chr10:102102088-102121442 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ldb1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    56 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos at E9.5-E10 with impaired primitive erythropoiesis and vascular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    85
  • GO References
    30
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    971
  • Tissues
    174
  • cDNA Data
    159
  • Literature Summary
    54
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025223 Ensembl Gene Model | MGI Sequence Detail 13645 C57BL/6J ±  kb
    transcript ENSMUST00000185355 Ensembl | MGI Sequence Detail 2088 Not Applicable  
    polypeptide ENSMUSP00000139562 Ensembl | MGI Sequence Detail 411 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 173
      Genomic 7
      cDNA 161
      Primer pair 2
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 121
      Developmental Gene Expression 54
      Diseases 1
      Gene Ontology 30
      Phenotypes 32
    • Earliest
      J:41552 Agulnick AD, et al., Interactions of the LIM-domain-binding factor Ldb1 with LIM homeodomain proteins. Nature. 1996 21;384(6606):270-2
    • Latest
      J:341393 Cheffer A, et al., DOT1L deletion impairs the development of cortical parvalbumin-expressing interneurons. Cereb Cortex. 2023 Sep 26;33(19):10272-10285
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory