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Dhh Gene Detail
Summary
  • Symbol
    Dhh
  • Name
    desert hedgehog
  • Feature Type
    protein coding gene
  • IDs
    MGI:94891
    NCBI Gene: 13363
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98789033-98796421 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 55.05 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    159 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94891
 protein coding gene Chr15:98779496-98796443 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022316
 protein coding gene Chr15:100662141-100667650 (-)
A/J MGP_AJ_G0022274
 protein coding gene Chr15:96682676-96688185 (-)
AKR/J MGP_AKRJ_G0022249
 protein coding gene Chr15:99659986-99665477 (-)
BALB/cJ MGP_BALBcJ_G0022281
 protein coding gene Chr15:96878472-96883969 (-)
C3H/HeJ MGP_C3HHeJ_G0022049
 protein coding gene Chr15:99709660-99715151 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022726
 protein coding gene Chr15:104404599-104412243 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020251
 protein coding gene Chr15:92600768-92606468 (-)
CAST/EiJ MGP_CASTEiJ_G0021572
 protein coding gene Chr15:100562138-100568783 (-)
CBA/J MGP_CBAJ_G0022018
 protein coding gene Chr15:107947578-107953069 (-)
DBA/2J MGP_DBA2J_G0022144
 protein coding gene Chr15:96131125-96136618 (-)
FVB/NJ MGP_FVBNJ_G0022124
 protein coding gene Chr15:95107124-95112623 (-)
LP/J MGP_LPJ_G0022216
 protein coding gene Chr15:100809628-100815127 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022144
 protein coding gene Chr15:111941868-111947379 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022741
 protein coding gene Chr15:99745073-99750558 (-)
PWK/PhJ MGP_PWKPhJ_G0021313
 protein coding gene Chr15:96251844-96257351 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021148
 protein coding gene Chr15:99595205-99600757 (-)
WSB/EiJ MGP_WSBEiJ_G0021622
 protein coding gene Chr15:100290051-100295558 (-)



Homology
more
  • Human Ortholog
    DHH, desert hedgehog signaling molecule
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DHH, desert hedgehog signaling molecule
  • Synonyms
    GDMN, GDXYM, HHG-3, SRXY7
  • Links
    NCBI Gene ID: 50846
    neXtProt AC: NX_O43323
    UniProt: O43323

  • Chr Location
    12q13.12; chr12:49086656-49094801 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dhh mouse models; 2 with human DHH associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 1 allele in 4 genetic backgrounds
    49 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are male sterile, failing to produce mature spermatozoa; peripheral nerves are abnormal, with thin and disorganized perineurial sheaths. High penetrance of pseudohermaphroditism observed on some mixed backgrounds.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1128
  • Tissues
    178
  • cDNA Data
    14
  • Literature Summary
    111
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023000 Ensembl Gene Model | MGI Sequence Detail 7389 C57BL/6J ±  kb
    transcript ENSMUST00000023737 Ensembl | MGI Sequence Detail 4242 Not Applicable  
    polypeptide ENSMUSP00000023737 Ensembl | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 2
      cDNA 15
      Primer pair 16
      Other 8

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-8842, MGI:2146288
    References
    more
    • Summaries
      All 198
      Developmental Gene Expression 111
      Diseases 2
      Gene Ontology 11
      Phenotypes 49
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:358076 Rouault P, et al., Thrombosis in the Coronary Microvasculature Impairs Cardiac Relaxation and Induces Diastolic Dysfunction. Arterioscler Thromb Vasc Biol. 2024 Jan;44(1):e1-e18
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory