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Dpp4 Gene Detail
Summary
  • Symbol
    Dpp4
  • Name
    dipeptidylpeptidase 4
  • Synonyms
    Cd26, Dpp-4, THAM
  • Feature Type
    protein coding gene
  • IDs
    MGI:94919
    NCBI Gene: 13482
  • Alliance
    gene page
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:62160417-62242575 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 35.85 cM, cytoband C2-D
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1938 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94919
 protein coding gene Chr2:62160417-62242635 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025769
 protein coding gene Chr2:62010555-62093488 (-)
A/J MGP_AJ_G0025745
 protein coding gene Chr2:59637050-59718808 (-)
AKR/J MGP_AKRJ_G0025715
 protein coding gene Chr2:61235189-61318612 (-)
BALB/cJ MGP_BALBcJ_G0025740
 protein coding gene Chr2:59737914-59825375 (-)
C3H/HeJ MGP_C3HHeJ_G0025501
 protein coding gene Chr2:61341547-61426683 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026187
 protein coding gene Chr2:63833519-63919160 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023591
 protein coding gene Chr2:57156592-57239212 (-)
CAST/EiJ MGP_CASTEiJ_G0024965
 protein coding gene Chr2:61409108-61494525 (-)
CBA/J MGP_CBAJ_G0025481
 protein coding gene Chr2:66249219-66341349 (-)
DBA/2J MGP_DBA2J_G0025612
 protein coding gene Chr2:59217228-59299486 (-)
FVB/NJ MGP_FVBNJ_G0025574
 protein coding gene Chr2:58737671-58820695 (-)
LP/J MGP_LPJ_G0025700
 protein coding gene Chr2:61840272-61927542 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025605
 protein coding gene Chr2:67943229-68029618 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026244
 protein coding gene Chr2:61303020-61388168 (-)
PWK/PhJ MGP_PWKPhJ_G0024706
 protein coding gene Chr2:59080955-59163500 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024513
 protein coding gene Chr2:61402361-61483471 (-)
WSB/EiJ MGP_WSBEiJ_G0025033
 protein coding gene Chr2:61617540-61700448 (-)



Homology
more
  • Human Ortholog
    DPP4, dipeptidyl peptidase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DPP4, dipeptidyl peptidase 4
  • Synonyms
    ADABP, ADCP2, CD26, DPPIV, TP103
  • Links
    NCBI Gene ID: 1803
    neXtProt AC: NX_P27487
    UniProt: P27487

  • Chr Location
    2q24.2; chr2:161992245-162074394 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Dpp4 mouse models; 2 with human DPP4 associations

Human Disease Mouse Models
      
IDs
 View 5 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 5 genetic backgrounds
    14 phenotypes from multigenic genotypes
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show hypoglycemia, hyperinsulinemia, and increased plasma glucagon-like peptide 1 in glucose tolerance tests.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    802
  • Tissues
    30
  • cDNA Data
    71
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035000 Ensembl Gene Model | MGI Sequence Detail 82159 C57BL/6J ±  kb
    transcript ENSMUST00000047812 Ensembl | MGI Sequence Detail 5268 Not Applicable  
    polypeptide ENSMUSP00000044050 Ensembl | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000001341 dipeptidyl peptidase 4
      (term hierarchy)
    • EC
      3.4.14.5
    • InterPro Domains
      IPR029058 Alpha/Beta hydrolase fold
      IPR040522 Dipeptidyl peptidase 4, low complexity region
      IPR002469 Dipeptidylpeptidase IV, N-terminal domain
      IPR001375 Peptidase S9, prolyl oligopeptidase, catalytic domain
      IPR002471 Peptidase S9, serine active site
      IPR050278 Serine Protease S9B/DPPIV Subfamily
    • GlyGen
      P28843 10 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 87
      Genomic 14
      cDNA 72
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1843, MGD-MRK-8884, MGD-MRK-8887
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 28
      Diseases 5
      Gene Ontology 11
      Phenotypes 83
    • Earliest
      J:1599 Marguet D, et al., cDNA cloning for mouse thymocyte-activating molecule. A multifunctional ecto-dipeptidyl peptidase IV (CD26) included in a subgroup of serine proteases. J Biol Chem. 1992 Feb 5;267(4):2200-8
    • Latest
      J:353426 Xia LY, et al., Isolation and characterization of a pangolin-borne HKU4-related coronavirus that potentially infects human-DPP4-transgenic mice. Nat Commun. 2024 Feb 5;15(1):1048
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory