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Dvl1 Gene Detail
Summary
  • Symbol
    Dvl1
  • Name
    dishevelled segment polarity protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94941
    NCBI Gene: 13542
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    5 QTL
Location &
Maps
more
  • Sequence Map
    Chr4:155931859-155943760 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 87.61 cM
  • Mapping Data
    17 experiments
Strain
Comparison
more
  • SNPs within 2kb
    490 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94941
 protein coding gene Chr4:155931829-155943760 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029233
 protein coding gene Chr4:160217062-160229791 (+)
A/J MGP_AJ_G0029198
 protein coding gene Chr4:153465418-153477667 (+)
AKR/J MGP_AKRJ_G0029146
 protein coding gene Chr4:157644521-157656436 (+)
BALB/cJ MGP_BALBcJ_G0029214
 protein coding gene Chr4:153939446-153951359 (+)
C3H/HeJ MGP_C3HHeJ_G0028935
 protein coding gene Chr4:158187052-158199069 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029663
 protein coding gene Chr4:165894804-165906705 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026908
 protein coding gene Chr4:145753862-145765891 (+)
CAST/EiJ MGP_CASTEiJ_G0028347
 protein coding gene Chr4:155658599-155670691 (+)
CBA/J MGP_CBAJ_G0028897
 protein coding gene Chr4:170909637-170921550 (+)
DBA/2J MGP_DBA2J_G0029046
 protein coding gene Chr4:153486601-153498514 (+)
FVB/NJ MGP_FVBNJ_G0029009
 protein coding gene Chr4:152735925-152747839 (+)
LP/J MGP_LPJ_G0029136
 protein coding gene Chr4:160145326-160157238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029036
 protein coding gene Chr4:173723342-173735256 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029695
 protein coding gene Chr4:158270580-158282492 (+)
PWK/PhJ MGP_PWKPhJ_G0028068
 protein coding gene Chr4:149630062-149642224 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027902
 protein coding gene Chr4:152529323-152541246 (+)
WSB/EiJ MGP_WSBEiJ_G0028427
 protein coding gene Chr4:158444593-158456508 (+)



Homology
more
  • Human Ortholog
    DVL1, dishevelled segment polarity protein 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DVL1, dishevelled segment polarity protein 1
  • Synonyms
    DRS2, DVL, DVL1L1, DVL1P1
  • Links
    NCBI Gene ID: 1855
    neXtProt AC: NX_O14640
    UniProt: O14640

  • Chr Location
    1p36.33; chr1:1335276-1349418 (-)  GRCh38
  • Human Ortholog
    DVL1P1, dishevelled segment polarity protein 1 pseudogene 1
  • Synonyms
    DSH, DVL, DVL1, DVL1L1, DVL-22, DVL4
  • Links
    NCBI Gene ID: 8215

  • Chr Location
    22q11.21,22q11; chr22:19253131-19253469 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human DVL1,DVL1P1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    25 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants are viable and fertile, but show a number of behavioral changes including deficient nest-building, less huddling contact during sleep, reduced subordinate responses, and other social interaction deficits.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    139
  • GO References
    48
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1045
  • Tissues
    189
  • cDNA Data
    81
  • Literature Summary
    36
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029071 Ensembl Gene Model | MGI Sequence Detail 11902 C57BL/6J ±  kb
transcript ENSMUST00000030948 Ensembl | MGI Sequence Detail 3358 Not Applicable  
polypeptide ENSMUSP00000030948 Ensembl | MGI Sequence Detail 695 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    Genomic 3
    cDNA 82
    Primer pair 9

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-8919
References
more
  • Summaries
    All 144
    Developmental Gene Expression 36
    Gene Ontology 48
    Phenotypes 26
  • Earliest
    J:2643 Beier DR, et al., Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9102-6
  • Latest
    J:355261 Rehmani T, et al., SLMAP3 is essential for neurulation through mechanisms involving cytoskeletal elements, ABP, and PCP. Life Sci Alliance. 2024 Dec;7(12)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory