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Ect2 Gene Detail
Summary
  • Symbol
    Ect2
  • Name
    ect2 oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:95281
    NCBI Gene: 13605
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:27151371-27207971 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 10.82 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1536 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95281
 protein coding gene Chr3:27151371-27208027 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027108
 protein coding gene Chr3:24401286-24462313 (-)
A/J MGP_AJ_G0027068
 protein coding gene Chr3:24226613-24282373 (-)
AKR/J MGP_AKRJ_G0027037
 protein coding gene Chr3:24522344-24580423 (-)
BALB/cJ MGP_BALBcJ_G0027080
 protein coding gene Chr3:23908035-23965293 (-)
C3H/HeJ MGP_C3HHeJ_G0026821
 protein coding gene Chr3:24568867-24628050 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027525
 protein coding gene Chr3:25754442-25818745 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024887
 protein coding gene Chr3:22248624-22306474 (-)
CAST/EiJ MGP_CASTEiJ_G0026276
 protein coding gene Chr3:24400772-24462069 (-)
CBA/J MGP_CBAJ_G0026799
 protein coding gene Chr3:26419208-26489240 (-)
DBA/2J MGP_DBA2J_G0026933
 protein coding gene Chr3:23779053-23836787 (-)
FVB/NJ MGP_FVBNJ_G0026901
 protein coding gene Chr3:23256275-23315237 (-)
LP/J MGP_LPJ_G0027045
 protein coding gene Chr3:25079514-25138125 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026922
 protein coding gene Chr3:29029422-29093236 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027585
 protein coding gene Chr3:24244254-24307426 (-)
PWK/PhJ MGP_PWKPhJ_G0026009
 protein coding gene Chr3:23237001-23294569 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025819
 protein coding gene Chr3:23800583-23857856 (-)
WSB/EiJ MGP_WSBEiJ_G0026349
 protein coding gene Chr3:24287584-24353464 (-)



Homology
more
  • Human Ortholog
    ECT2, epithelial cell transforming 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ECT2, epithelial cell transforming 2
  • Synonyms
    ARHGEF31
  • Links
    NCBI Gene ID: 1894
    neXtProt AC: NX_Q9H8V3
    UniProt: Q9H8V3

  • Chr Location
    3q26.31; chr3:172750682-172829265 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this locus is embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    783
  • Tissues
    9
  • cDNA Data
    140
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13605 NCBI Gene Model | MGI Sequence Detail 56601 C57BL/6J ±  kb
    transcript NM_001409706 RefSeq | MGI Sequence Detail 4165 C57BL/6  
    polypeptide Q07139 UniProt | EBI | MGI Sequence Detail 913 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 143
      Genomic 1
      cDNA 140
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-9296, MGI:2139751
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:4309 Miki T, et al., Oncogene ect2 is related to regulators of small GTP-binding proteins [published erratum appears in Nature 1993 Aug 19;364(6439):737]. Nature. 1993 Apr 1;362(6419):462-5
    • Latest
      J:353553 Despin-Guitard E, et al., Non-apical mitoses contribute to cell delamination during mouse gastrulation. Nat Commun. 2024 Aug 28;15(1):7364
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory