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Egf Gene Detail
Summary
  • Symbol
    Egf
  • Name
    epidermal growth factor
  • Feature Type
    protein coding gene
  • IDs
    MGI:95290
    NCBI Gene: 13645
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:129471223-129548971 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 58.50 cM
  • Mapping Data
    40 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2425 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95290
 protein coding gene Chr3:129471214-129548971 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027871
 protein coding gene Chr3:132340864-132423833 (-)
A/J MGP_AJ_G0027829
 protein coding gene Chr3:127745912-127824237 (-)
AKR/J MGP_AKRJ_G0027794
 protein coding gene Chr3:131054804-131132943 (-)
BALB/cJ MGP_BALBcJ_G0027842
 protein coding gene Chr3:127586010-127664029 (-)
C3H/HeJ MGP_C3HHeJ_G0027571
 protein coding gene Chr3:131447569-131527664 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028286
 protein coding gene Chr3:137083095-137165997 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025624
 protein coding gene Chr3:123270021-123349436 (-)
CAST/EiJ MGP_CASTEiJ_G0027028
 protein coding gene Chr3:131124153-131203503 (-)
CBA/J MGP_CBAJ_G0027547
 protein coding gene Chr3:141697335-141781703 (-)
DBA/2J MGP_DBA2J_G0027688
 protein coding gene Chr3:126937709-127016389 (-)
FVB/NJ MGP_FVBNJ_G0027655
 protein coding gene Chr3:124519136-124600301 (-)
LP/J MGP_LPJ_G0027797
 protein coding gene Chr3:133853600-133935853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027686
 protein coding gene Chr3:149646827-149731557 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028343
 protein coding gene Chr3:130723018-130807838 (-)
PWK/PhJ MGP_PWKPhJ_G0026752
 protein coding gene Chr3:126668079-126802107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026577
 protein coding gene Chr3:128786178-128868863 (-)
WSB/EiJ MGP_WSBEiJ_G0027107
 protein coding gene Chr3:131435640-131519492 (-)



Homology
more
  • Human Ortholog
    EGF, epidermal growth factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EGF, epidermal growth factor
  • Synonyms
    HOMG4, URG
  • Links
    NCBI Gene ID: 1950
    neXtProt AC: NX_P01133
    UniProt: P01133

  • Chr Location
    4q25; chr4:109912883-110013766 (+)  GRCh38
Human Diseases
more
  • Diseases
    11 with human EGF associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    19 phenotypes from multigenic genotypes
    20 phenotype references
Null mutants have normal phenotype. Females triply null, for this locus and the amphiregulin and transforming growth factor alpha genes, are unable to nurse due to impaired mammary gland development and show mild integument and digestive system anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    37
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    905
  • Tissues
    119
  • cDNA Data
    140
  • Literature Summary
    52
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13645 NCBI Gene Model | MGI Sequence Detail 77749 C57BL/6J ±  kb
transcript NM_010113 RefSeq | MGI Sequence Detail 4773 ZRU/MplStud  
polypeptide P01132 UniProt | EBI | MGI Sequence Detail 1217 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 162
    Genomic 3
    cDNA 143
    Primer pair 14
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-9315, MGI:2139798
References
more
  • Summaries
    All 268
    Developmental Gene Expression 52
    Diseases 1
    Gene Ontology 37
    Phenotypes 20
  • Earliest
    J:70074 Nexo E, et al., Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development. Proc Natl Acad Sci U S A. 1980 May;77(5):2782-5
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory