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Eif4e Gene Detail
Summary
  • Symbol
    Eif4e
  • Name
    eukaryotic translation initiation factor 4E
  • Synonyms
    eIF-4E, If4e
  • Feature Type
    protein coding gene
  • IDs
    MGI:95305
    NCBI Gene: 13684
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:138231952-138265457 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 64.30 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    699 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95305
 protein coding gene Chr3:138231940-138265457 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027933
 protein coding gene Chr3:141578015-141617536 (+)
A/J MGP_AJ_G0027890
 protein coding gene Chr3:136566600-136601520 (+)
AKR/J MGP_AKRJ_G0027856
 protein coding gene Chr3:140195382-140228848 (+)
BALB/cJ MGP_BALBcJ_G0027902
 protein coding gene Chr3:136377458-136412031 (+)
C3H/HeJ MGP_C3HHeJ_G0027632
 protein coding gene Chr3:140535774-140569922 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028346
 protein coding gene Chr3:146471080-146505600 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025684
 protein coding gene Chr3:131991679-132017676 (+)
CAST/EiJ MGP_CASTEiJ_G0027088
 protein coding gene Chr3:140314808-140351120 (+)
CBA/J MGP_CBAJ_G0027609
 protein coding gene Chr3:151454422-151490421 (+)
DBA/2J MGP_DBA2J_G0027748
 protein coding gene Chr3:135693624-135729887 (+)
FVB/NJ MGP_FVBNJ_G0027715
 protein coding gene Chr3:133153208-133189450 (+)
LP/J MGP_LPJ_G0027858
 protein coding gene Chr3:142982236-143022313 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027747
 protein coding gene Chr3:159553116-159586677 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028404
 protein coding gene Chr3:139748436-139782614 (+)
PWK/PhJ MGP_PWKPhJ_G0026812
 protein coding gene Chr3:135464192-135492582 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026639
 protein coding gene Chr3:137867791-137898823 (+)
WSB/EiJ MGP_WSBEiJ_G0027167
 protein coding gene Chr3:140602712-140637519 (+)



Homology
more
  • Human Ortholog
    EIF4E, eukaryotic translation initiation factor 4E
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF4E, eukaryotic translation initiation factor 4E
  • Synonyms
    AUTS19, CBP, eIF-4E, EIF4E1, EIF4EL1, EIF4F
  • Links
    NCBI Gene ID: 1977
    neXtProt AC: NX_P06730
    UniProt: P06730

  • Chr Location
    4q23; chr4:98879276-98929133 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Eif4e mouse models; 1 with human EIF4E associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 4 alleles in 6 genetic backgrounds
    15 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit resistance to developing prostate intraepithelial neoplasia. Embryos homozygous for a transposon-induced knock-out allele exhibit peri-implantation lethality, failure of normal epiblast formation, and decreased translational activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    95
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    832
  • Tissues
    34
  • cDNA Data
    16
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13684 NCBI Gene Model | MGI Sequence Detail 33506 C57BL/6J ±  kb
    transcript NM_001313980 RefSeq | MGI Sequence Detail 5031 ZRU/MplStud  
    polypeptide P63073 UniProt | EBI | MGI Sequence Detail 217 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 1
      cDNA 17
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11199, MGD-MRK-9339, MGI:3649046
    References
    more
    • Summaries
      All 137
      Developmental Gene Expression 19
      Diseases 3
      Gene Ontology 24
      Phenotypes 46
    • Earliest
      J:9886 Altmann M, et al., A mammalian translation initiation factor can substitute for its yeast homologue in vivo. J Biol Chem. 1989 Jul 25;264(21):12145-7
    • Latest
      J:349721 Borisova E, et al., Protein translation rate determines neocortical neuron fate. Nat Commun. 2024 Jun 7;15(1):4879
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory