Fcgr2b MGI Mouse Gene Detail - MGI:95499 - Fc receptor, IgG, low affinity IIb

Symbol

Fcgr2b
Name

Fc receptor, IgG, low affinity IIb
Synonyms

CD32, F630109E10Rik, Fc gamma RIIB, FcgammaRIIB, Fcgr2, Fcgr2a, Fc[g]RII, FcgRII, Fcr-2, Fcr-3, Ly-17, LyM-1, Ly-m20

Feature Type

protein coding gene
IDs

MGI:95499
NCBI Gene: 14130
Alliance

gene page
Transcription Start Sites

18 TSS
Candidate for QTL

4 QTL

Sequence Map

Chr1:170786186-170804116 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 78.02 cM
Mapping Data

75 experiments

SNPs within 2kb

655 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95499	protein coding gene	Chr1:170786186-170804141 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016738	protein coding gene	Chr1:176705571-176728687 (-)
A/J	MGP_AJ_G0016718	protein coding gene	Chr1:169500102-169518087 (-)
AKR/J	MGP_AKRJ_G0016684	protein coding gene	Chr1:174593786-174612816 (-)
BALB/cJ	MGP_BALBcJ_G0016679	protein coding gene	Chr1:169974583-169992885 (-)
C3H/HeJ	MGP_C3HHeJ_G0016502	protein coding gene	Chr1:174828448-174845494 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017140	protein coding gene	Chr1:182563068-182581438 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014849	protein coding gene	Chr1:161211144-161229017 (-)
CAST/EiJ	MGP_CASTEiJ_G0016083	protein coding gene	Chr1:174462601-174480771 (-)
CBA/J	MGP_CBAJ_G0016477	protein coding gene	Chr1:189049117-189070734 (-)
DBA/2J	MGP_DBA2J_G0016584	protein coding gene	Chr1:168349656-168367485 (-)
FVB/NJ	MGP_FVBNJ_G0016580	protein coding gene	Chr1:166709842-166727009 (-)
LP/J	MGP_LPJ_G0016655	protein coding gene	Chr1:177825833-177845880 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016607	protein coding gene	Chr1:196353339-196372360 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017177	protein coding gene	Chr1:174475791-174494629 (-)
PWK/PhJ	MGP_PWKPhJ_G0015869	protein coding gene	Chr1:167592877-167610675 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015653	protein coding gene	Chr1:173228211-173244562 (-)
WSB/EiJ	MGP_WSBEiJ_G0016145	protein coding gene	Chr1:174597644-174617537 (-)

Human Ortholog

FCGR2A, Fc gamma receptor IIa

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FCGR2A, Fc gamma receptor IIa
Synonyms

CD32, CD32A, CDw32, FCG2, FcgammaRIIa, FcGR, FCGR2, FCGR2A1, IGFR2
Links

HGNC:3616

NCBI Gene ID: 2212

neXtProt AC: NX_P12318

UniProt: P12318
Chr Location

1q23.3; chr1:161505430-161524048 (+) GRCh38

Human Ortholog

FCGR2B, Fc gamma receptor IIb
Synonyms

CD32, CD32B, FCG2, FcgammaRIIb, FCGR2, FCGR2C, FcGRIIB, FcRII-c, IGFR2
Links

HGNC:3618

NCBI Gene ID: 2213

neXtProt AC: NX_P31994

UniProt: P31994
Chr Location

1q23.3; chr1:161647243-161678654 (+) GRCh38

Human Ortholog

FCGR2C, Fc gamma receptor IIc (gene/pseudogene)
Synonyms

CD32, CD32C, CDW32, FCG2, FcgammaRIIc, FCRIIC, IGFR2
Links

HGNC:15626

NCBI Gene ID: 9103

neXtProt AC: NX_P31995

UniProt: P31995
Chr Location

1q23.3; chr1:161581339-161605662 (+) GRCh38

MGI Vertebrate Homology

Fcgr2b stringent orthology
3 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FCGR2A, FCGR2B, FCGR2C
Gene Tree

Fcgr2b

Diseases

2 with Fcgr2b mouse models; 32 with human FCGR2A,FCGR2B associations

Human Disease

Mouse Models

malaria

IDs

View 1 model

systemic lupus erythematosus

IDs

View 2 models

arthus reaction

IDs

atherosclerosis

IDs

autoimmune thrombocytopenic purpura

IDs

coronary artery disease

IDs

Crohn's disease

IDs

cystic fibrosis

IDs

dengue disease

IDs

dengue hemorrhagic fever

IDs

diffuse large B-cell lymphoma

IDs

diffuse scleroderma

IDs

factor VIII deficiency

IDs

glomerulonephritis

IDs

haemophilus meningitis

IDs

hemolytic anemia

IDs

hemolytic disease of the fetus

IDs

IDs

IDs

IDs

IDs

IDs

IDs

IDs

Plasmodium falciparum malaria

IDs

respiratory system disease

IDs

IDs

IDs

IDs

IDs

IDs

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

4 with disease annotations

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Phenotype Summary

41 phenotypes from 4 alleles in 6 genetic backgrounds
50 phenotypes from multigenic genotypes
1 images
309 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Chemically induced (other)

2
Endonuclease-mediated

10
Gene trapped

6
Spontaneous

1
Targeted

10
Genomic Mutations

6 involving Fcgr2b
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

49 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutants show increased antibody response, passive cutaneous analphylaxis, autoantibodies and arthritis susceptibility. On C57BL/6, mice die by 9 months with anemia, proteinuria, glomerulonephritis, and inflammatory disease. A strain variant controls expression in germinal center B cells.

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All GO Annotations

68
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

721
Tissues

13
cDNA Data

53
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

75
RefSeq

18
UniProt

4
CCDS

CCDS35769.1, CCDS35770.1

Ensembl

ENSMUSG00000026656 (Evidence)
NCBI Gene

14130

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026656	Ensembl Gene Model \| MGI Sequence Detail	17931	C57BL/6J	± kb
transcript	ENSMUST00000027966	Ensembl \| MGI Sequence Detail	3544	Not Applicable
polypeptide	ENSMUSP00000027966	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001479 low affinity immunoglobulin gamma Fc region receptor II

(term hierarchy)
InterPro Domains

IPR050488 Immunoglobulin Fc region receptor

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype
GlyGen

P08101 6 sites, 37 N-linked glycans (6 sites)

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All nucleic 66

Genomic 6

cDNA 57

Primer pair 3

Microarray probesets 3

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MGD-MRK-11955, MGD-MRK-12013, MGD-MRK-12069, MGD-MRK-12070, MGD-MRK-9733, MGD-MRK-9734, MGD-MRK-9735, MGD-MRK-9739, MGD-MRK-9740, MGI:2138286, MGI:2445072

Summaries

All 473

Developmental Gene Expression 6

Diseases 4

Gene Ontology 17

Phenotypes 309
Earliest

J:5896 Dickler HB, et al., B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus. J Exp Med. 1977 Dec 1;146(6):1678-92
Latest

J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10

TSS for Fcgr2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14965	Chr1:170804136-170804177 (-)	-41 bp
Tssr14964	Chr1:170803681-170803689 (-)	431 bp
Tssr14963	Chr1:170803613-170803675 (-)	472 bp
Tssr14962	Chr1:170803592-170803607 (-)	516 bp
Tssr14961	Chr1:170803573-170803584 (-)	537 bp
Tssr14960	Chr1:170800428-170800436 (-)	3,684 bp
Tssr14959	Chr1:170799528-170799530 (-)	4,587 bp
Tssr14958	Chr1:170795773-170795794 (-)	8,332 bp
Tssr14957	Chr1:170794054-170794092 (-)	10,043 bp
Tssr14956	Chr1:170793364-170793380 (-)	10,744 bp
Tssr14955	Chr1:170788654-170788674 (-)	15,452 bp
Tssr14954	Chr1:170788425-170788436 (-)	15,685 bp
Tssr14953	Chr1:170787658-170787669 (-)	16,452 bp
Tssr14952	Chr1:170787643-170787654 (-)	16,467 bp
Tssr284	Chr1:170787463-170787468 (-)	16,650 bp
Tssr14951	Chr1:170787386-170787409 (-)	16,718 bp
Tssr14950	Chr1:170787308-170787340 (-)	16,792 bp
Tssr14949	Chr1:170786464-170786486 (-)	17,641 bp

Fcgr2b is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Lmr20	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Lmr20a	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Lmr20b	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].
Lmr20c	Chr1, syntenic	Chr1:175468817-175468938	J:152405	Potential candidated genes mapping near Lmr20, Lmr20a, Lmr20b and Lmr20c which mapped to D1Mit403 at 100.0 cM of CcS11/Dem in this study are: Fcer1a, Fc receptor, IgE, high affinity I, alpha polypeptide at 94.2 cM; Fcer1g, Fc receptor, IgE, high affinity I, gamma polypeptide at 93.3 cM; Fcgr2b, Fc receptor, IgG, low affinity IIb at 92.3 cM; Cluster of IFN activated genes: Ifi201,Ifi202a; Ifi203, and Ifi204 between 95.2-95.3 cM; and Tgfb2, transforming growth factor, beta 2 at 101.5 cM. [Table 9.] Possibly related QTL controlling other infections and co-localizing with the Lmr20 QTL are: Tir3c, trypanosome infection response 3c at 93.0 cM; Ssta2, susceptibility to Salmonella typhimurium antigens 2 at 95.8 cM; Bbaa12, B.burgdorferi-associated arthritis 12 at 96.0 cM; and, Berr1, berghei resistance locus 1 at 102.0 cM; [Table 10].

*cM position of peak correlated region/marker

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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