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Fgfr4 Gene Detail
Summary
  • Symbol
    Fgfr4
  • Name
    fibroblast growth factor receptor 4
  • Synonyms
    Fgfr-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95525
    NCBI Gene: 14186
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:55300631-55316572 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 29.80 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    461 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95525
 protein coding gene Chr13:55300453-55316572 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020587
 protein coding gene Chr13:54605737-54621154 (+)
A/J MGP_AJ_G0020541
 protein coding gene Chr13:52597822-52613248 (+)
AKR/J MGP_AKRJ_G0020519
 protein coding gene Chr13:54144119-54159545 (+)
BALB/cJ MGP_BALBcJ_G0020537
 protein coding gene Chr13:52829114-52844667 (+)
C3H/HeJ MGP_C3HHeJ_G0020336
 protein coding gene Chr13:53962701-53978997 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020971
 protein coding gene Chr13:56266655-56284348 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018553
 protein coding gene Chr13:50558674-50574436 (+)
CAST/EiJ MGP_CASTEiJ_G0019850
 protein coding gene Chr13:54055565-54071772 (+)
CBA/J MGP_CBAJ_G0020296
 protein coding gene Chr13:58400610-58420192 (+)
DBA/2J MGP_DBA2J_G0020419
 protein coding gene Chr13:52151392-52167338 (+)
FVB/NJ MGP_FVBNJ_G0020398
 protein coding gene Chr13:51613287-51628760 (+)
LP/J MGP_LPJ_G0020495
 protein coding gene Chr13:54880785-54895973 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020427
 protein coding gene Chr13:57905275-57921773 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021014
 protein coding gene Chr13:53725436-53741948 (+)
PWK/PhJ MGP_PWKPhJ_G0019606
 protein coding gene Chr13:52179631-52195683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019433
 protein coding gene Chr13:52652286-52667919 (+)
WSB/EiJ MGP_WSBEiJ_G0019912
 protein coding gene Chr13:54076778-54093453 (+)



Homology
more
  • Human Ortholog
    FGFR4, fibroblast growth factor receptor 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGFR4, fibroblast growth factor receptor 4
  • Synonyms
    CD334, JTK2, TKF
  • Links
    NCBI Gene ID: 2264
    neXtProt AC: NX_P22455
    UniProt: P22455

  • Chr Location
    5q35.2; chr5:177086905-177098144 (+)  GRCh38
Human Diseases
more
  • Diseases
    9 with human FGFR4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 4 alleles in 4 genetic backgrounds
    14 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation are viable, healthy and overtly normal, except for a 10% weight reduction at weaning. Mice doubly homozygous for disruptions of Fgfr3 and Fgfr4 show novel phenotypes not seen in either single mutant, including dwarfismand defective respiratory alveogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    100
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1373
  • Tissues
    350
  • cDNA Data
    39
  • Literature Summary
    95
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14186 NCBI Gene Model | MGI Sequence Detail 15942 C57BL/6J ±  kb
    transcript NM_008011 RefSeq | MGI Sequence Detail 3146 ZRU/MplStud  
    polypeptide Q03142 UniProt | EBI | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 40
      Primer pair 21
      Other 10

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9779, MGD-MRK-9784
    References
    more
    • Summaries
      All 210
      Developmental Gene Expression 95
      Diseases 3
      Gene Ontology 19
      Phenotypes 55
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory