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Fgr Gene Detail
Summary
  • Symbol
    Fgr
  • Name
    FGR proto-oncogene, Src family tyrosine kinase
  • Synonyms
    Ali18, Mhdaali18
  • Feature Type
    protein coding gene
  • IDs
    MGI:95527
    NCBI Gene: 14191
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:132701406-132729204 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 66.11 cM
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    990 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95527
 protein coding gene Chr4:132701406-132729221 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028884
 protein coding gene Chr4:135182147-135215364 (+)
A/J MGP_AJ_G0028843
 protein coding gene Chr4:129546280-129576540 (+)
AKR/J MGP_AKRJ_G0028796
 protein coding gene Chr4:133208886-133238901 (+)
BALB/cJ MGP_BALBcJ_G0028866
 protein coding gene Chr4:130164163-130191861 (+)
C3H/HeJ MGP_C3HHeJ_G0028580
 protein coding gene Chr4:133460557-133491116 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029308
 protein coding gene Chr4:140040017-140075466 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026579
 protein coding gene Chr4:122619404-122648170 (+)
CAST/EiJ MGP_CASTEiJ_G0028013
 protein coding gene Chr4:131553529-131586145 (+)
CBA/J MGP_CBAJ_G0028546
 protein coding gene Chr4:143653531-143689347 (+)
DBA/2J MGP_DBA2J_G0028695
 protein coding gene Chr4:129965029-129993783 (+)
FVB/NJ MGP_FVBNJ_G0028662
 protein coding gene Chr4:128826724-128855308 (+)
LP/J MGP_LPJ_G0028796
 protein coding gene Chr4:135318015-135346506 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028688
 protein coding gene Chr4:148239869-148269188 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029346
 protein coding gene Chr4:133618421-133652046 (+)
PWK/PhJ MGP_PWKPhJ_G0027734
 protein coding gene Chr4:126665819-126694885 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027560
 protein coding gene Chr4:129477934-129509078 (+)
WSB/EiJ MGP_WSBEiJ_G0028093
 protein coding gene Chr4:133790894-133824633 (+)



Homology
more
  • Human Ortholog
    FGR, FGR proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGR, FGR proto-oncogene, Src family tyrosine kinase
  • Synonyms
    c-fgr, c-src2, p55c-fgr, p55-Fgr, p58c-fgr, p58-Fgr, SRC2
  • Links
    NCBI Gene ID: 2268
    neXtProt AC: NX_P09769
    UniProt: P09769

  • Chr Location
    1p35.3; chr1:27612064-27635185 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a partial reduction in hemorrhage following induction of a local Shwartzman reaction, and show enhanced NK-cell receptor-induced IFN-gamma production in natural killer (NK) cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    727
  • Tissues
    21
  • cDNA Data
    20
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14191 NCBI Gene Model | MGI Sequence Detail 27799 C57BL/6J ±  kb
    transcript NM_010208 RefSeq | MGI Sequence Detail 3353 ZRU/MplStud  
    polypeptide P14234 UniProt | EBI | MGI Sequence Detail 517 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 4
      cDNA 21
      Primer pair 1
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9787, MGI:3665435
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 3
      Gene Ontology 14
      Phenotypes 68
    • Earliest
      J:7829 Parker RC, et al., Isolation of duplicated human c-src genes located on chromosomes 1 and 20. Mol Cell Biol. 1985 Apr;5(4):831-8
    • Latest
      J:335773 Futosi K, et al., Analysis of intracellular tyrosine phosphorylation in circulating neutrophils as a rapid assay for the in vivo effect of oral tyrosine kinase inhibitors. Front Pharmacol. 2023;14:1056154
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory