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Flt1 Gene Detail
Summary
  • Symbol
    Flt1
  • Name
    FMS-like tyrosine kinase 1
  • Synonyms
    Flt-1, sFlt1, vascular endothelial growth factor receptor-1, VEGFR-1, VEGFR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95558
    NCBI Gene: 14254
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:147498414-147662821 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 87.01 cM, cytoband G
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5339 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95558
 protein coding gene Chr5:147498414-147663419 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030391
 protein coding gene Chr5:153239322-153417102 (-)
A/J MGP_AJ_G0030364
 protein coding gene Chr5:146733377-146901260 (-)
AKR/J MGP_AKRJ_G0030291
 protein coding gene Chr5:151244298-151413430 (-)
BALB/cJ MGP_BALBcJ_G0030373
 protein coding gene Chr5:147948976-148120605 (-)
C3H/HeJ MGP_C3HHeJ_G0030087
 protein coding gene Chr5:152221203-152389205 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030828
 protein coding gene Chr5:158843447-159036006 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028041
 protein coding gene Chr5:141139974-141303106 (-)
CAST/EiJ MGP_CASTEiJ_G0029489
 protein coding gene Chr5:151786890-151966819 (-)
CBA/J MGP_CBAJ_G0030065
 protein coding gene Chr5:165502094-165689832 (-)
DBA/2J MGP_DBA2J_G0030209
 protein coding gene Chr5:146411809-146581167 (-)
FVB/NJ MGP_FVBNJ_G0030163
 protein coding gene Chr5:145614493-145783643 (-)
LP/J MGP_LPJ_G0030296
 protein coding gene Chr5:153926384-154108220 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030199
 protein coding gene Chr5:167725300-167913943 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030858
 protein coding gene Chr5:151153206-151324763 (-)
PWK/PhJ MGP_PWKPhJ_G0029203
 protein coding gene Chr5:145519256-145694160 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029039
 protein coding gene Chr5:148469187-148658525 (-)
WSB/EiJ MGP_WSBEiJ_G0029566
 protein coding gene Chr5:151965060-152139832 (-)



Homology
more
  • Human Ortholog
    FLT1, fms related receptor tyrosine kinase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FLT1, fms related receptor tyrosine kinase 1
  • Synonyms
    FLT, FLT-1, VEGFR-1, VEGFR1
  • Links
    NCBI Gene ID: 2321
    neXtProt AC: NX_P17948
    UniProt: P17948

  • Chr Location
    13q12.3; chr13:28300346-28495145 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human FLT1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 9 alleles in 13 genetic backgrounds
    17 phenotypes from multigenic genotypes
    99 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit an excess of hemangioblasts resulting in an overgrowth of endothelial cells, abnormalities of vascular channels and blood islands, and lethality at the mid-somite developmental stage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1176
  • Tissues
    216
  • cDNA Data
    26
  • Literature Summary
    212
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029648 Ensembl Gene Model | MGI Sequence Detail 164408 C57BL/6J ±  kb
    transcript ENSMUST00000031653 Ensembl | MGI Sequence Detail 6895 Not Applicable  
    polypeptide ENSMUSP00000031653 Ensembl | MGI Sequence Detail 1333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000007563 vascular endothelial growth factor receptor 1
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR013151 Immunoglobulin
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR042495 Platelet-derived growth factor receptor-like protein
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR001824 Tyrosine-protein kinase, receptor class III, conserved site
      IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)
      IPR041348 VEGFR-2, transmembrane domain
    • GlyGen
      P35969 14 sites, 7 N-linked glycans (11 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 1
      cDNA 29
      Primer pair 30
      Other 15

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-9832, MGD-MRK-9836, MGI:2140833
    References
    more
    • Summaries
      All 400
      Developmental Gene Expression 212
      Gene Ontology 24
      Phenotypes 99
    • Earliest
      J:36463 Raz V, et al., PCR-based identification of new receptors: molecular cloning of a receptor for fibroblast growth factors. Oncogene. 1991 May;6(5):753-60
    • Latest
      J:352471 Yoshida S, et al., Primary Cilia are Required for Cell-Type Determination and Angiogenesis in Pituitary Development. Endocrinology. 2024 Jul 1;165(8)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory