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Gas2 Gene Detail
Summary
  • Symbol
    Gas2
  • Name
    growth arrest specific 2
  • Synonyms
    Gas-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95657
    NCBI Gene: 14453
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:51511763-51644723 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 32.87 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3655 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95657
 protein coding gene Chr7:51511560-51644753 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032307
 protein coding gene Chr7:52627464-52762553 (+)
A/J MGP_AJ_G0032286
 protein coding gene Chr7:51794557-51942755 (+)
AKR/J MGP_AKRJ_G0032222
 protein coding gene Chr7:53011774-53151482 (+)
BALB/cJ MGP_BALBcJ_G0032298
 protein coding gene Chr7:51444868-51587017 (+)
C3H/HeJ MGP_C3HHeJ_G0032011
 protein coding gene Chr7:53415217-53555101 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032791
 protein coding gene Chr7:54995361-55134263 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029798
 protein coding gene Chr7:54811099-54939546 (+)
CAST/EiJ MGP_CASTEiJ_G0031340
 protein coding gene Chr7:44738438-44880543 (+)
CBA/J MGP_CBAJ_G0031976
 protein coding gene Chr7:56854307-57016904 (+)
DBA/2J MGP_DBA2J_G0032133
 protein coding gene Chr7:50974252-51109092 (+)
FVB/NJ MGP_FVBNJ_G0032087
 protein coding gene Chr7:50899583-51033045 (+)
LP/J MGP_LPJ_G0032214
 protein coding gene Chr7:53577109-53714934 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032124
 protein coding gene Chr7:55961508-56118807 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032808
 protein coding gene Chr7:51990466-52137645 (+)
PWK/PhJ MGP_PWKPhJ_G0031060
 protein coding gene Chr7:44279059-44414929 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030901
 protein coding gene Chr7:40147944-40284798 (+)
WSB/EiJ MGP_WSBEiJ_G0031458
 protein coding gene Chr7:52692466-52833464 (+)



Homology
more
  • Human Ortholog
    GAS2, growth arrest specific 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GAS2, growth arrest specific 2
  • Synonyms
    DFNB125, GAS-2
  • Links
    NCBI Gene ID: 2620
    neXtProt AC: NX_O43903
    UniProt: O43903

  • Chr Location
    11p14.3; chr11:22625509-22813055 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gas2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null females have reduced fertility. Oocyte cyst breakdown is disrupted and follicle growth is impaired, with reduced antral follicle and corpora lutea numbers, and disrupted basal lamina surrounding follicles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    71
  • cDNA Data
    11
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030498 Ensembl Gene Model | MGI Sequence Detail 132961 C57BL/6J ±  kb
    transcript ENSMUST00000051912 Ensembl | MGI Sequence Detail 2181 Not Applicable  
    polypeptide ENSMUSP00000053514 Ensembl | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-9987, MGD-MRK-9994
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:9302 Schneider C, et al., Genes specifically expressed at growth arrest of mammalian cells. Cell. 1988 Sep 9;54(6):787-93
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory