About   Help   FAQ
Gata4 Gene Detail
Summary
  • Symbol
    Gata4
  • Name
    GATA binding protein 4
  • Synonyms
    Gata-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95664
    NCBI Gene: 14463
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:63436371-63509141 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 33.24 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1902 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95664
 protein coding gene Chr14:63436363-63509161 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021459
 protein coding gene Chr14:57689507-57776742 (-)
A/J MGP_AJ_G0021418
 protein coding gene Chr14:56396414-56471939 (-)
AKR/J MGP_AKRJ_G0021394
 protein coding gene Chr14:58410057-58483163 (-)
BALB/cJ MGP_BALBcJ_G0021424
 protein coding gene Chr14:56349700-56433538 (-)
C3H/HeJ MGP_C3HHeJ_G0021201
 protein coding gene Chr14:58020808-58097491 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021863
 protein coding gene Chr14:60447433-60528613 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019403
 protein coding gene Chr14:54354954-54427595 (-)
CAST/EiJ MGP_CASTEiJ_G0020718
 protein coding gene Chr14:54473247-54549426 (-)
CBA/J MGP_CBAJ_G0021168
 protein coding gene Chr14:62241597-62321494 (-)
DBA/2J MGP_DBA2J_G0021291
 protein coding gene Chr14:56078936-56151725 (-)
FVB/NJ MGP_FVBNJ_G0021270
 protein coding gene Chr14:55464374-55539604 (-)
LP/J MGP_LPJ_G0021366
 protein coding gene Chr14:58721658-58797294 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021299
 protein coding gene Chr14:61504467-61590060 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021886
 protein coding gene Chr14:57548587-57631255 (-)
PWK/PhJ MGP_PWKPhJ_G0020462
 protein coding gene Chr14:52739491-52820013 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020295
 protein coding gene Chr14:53519451-53598368 (-)
WSB/EiJ MGP_WSBEiJ_G0020771
 protein coding gene Chr14:57875012-57951151 (-)



Homology
more
  • Human Ortholog
    GATA4, GATA binding protein 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GATA4, GATA binding protein 4
  • Synonyms
    ASD2, TACHD, TOF, VSD1
  • Links
    NCBI Gene ID: 2626
    neXtProt AC: NX_P43694
    UniProt: P43694

  • Chr Location
    8p23.1; chr8:11676935-11760002 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gata4 mouse models; 6 with human GATA4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
      
IDs
IDs
 View 1 model
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    141 phenotypes from 14 alleles in 19 genetic backgrounds
    55 phenotypes from multigenic genotypes
    14 images
    144 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show defects in ventral morphogenesis, lack a primitive heart tube and foregut, develop partially outside the yolk sac and die by midgestation. Heterozygotes show neonatal death, defects in heart, lungs or diaphragm, delayed female puberty and impaired ovarian response to gonadotropins. Homozygosity for phosphorylation-blocking mutation p.S105A leads to reduced testosterone levels and seminal vesicle weight in males.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    156
  • GO References
    63
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1988
  • Tissues
    390
  • cDNA Data
    40
  • Literature Summary
    523
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021944 Ensembl Gene Model | MGI Sequence Detail 72771 C57BL/6J ±  kb
    transcript ENSMUST00000067417 Ensembl | MGI Sequence Detail 3400 Not Applicable  
    polypeptide ENSMUSP00000066927 Ensembl | MGI Sequence Detail 442 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 115
      Genomic 4
      cDNA 43
      Primer pair 50
      Other 18

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10001, MGD-MRK-10005
    References
    more
    • Summaries
      All 724
      Developmental Gene Expression 523
      Diseases 4
      Gene Ontology 63
      Phenotypes 144
    • Earliest
      J:4641 Arceci RJ, et al., Mouse GATA-4: a retinoic acid-inducible GATA-binding transcription factor expressed in endodermally derived tissues and heart. Mol Cell Biol. 1993 Apr;13(4):2235-46
    • Latest
      J:354194 Oikonomakos I, et al., In vitro differentiation of mouse pluripotent stem cells into corticosteroid-producing adrenocortical cells. Stem Cell Reports. 2024 Sep 10;19(9):1289-1303
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory