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Gcnt1 Gene Detail
Summary
  • Symbol
    Gcnt1
  • Name
    glucosaminyl (N-acetyl) transferase 1, core 2
  • Synonyms
    5630400D21Rik, beta-1, 6-N-acetylglucosaminyltransferase, C2 GlcNAcT, IGnT
  • Feature Type
    protein coding gene
  • IDs
    MGI:95676
    NCBI Gene: 14537
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:17303505-17350208 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 12.75 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1712 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95676
 protein coding gene Chr19:17303505-17350208 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024963
 protein coding gene Chr19:15144818-15180745 (-)
A/J MGP_AJ_G0024940
 protein coding gene Chr19:14257271-14290511 (-)
AKR/J MGP_AKRJ_G0024910
 protein coding gene Chr19:14828291-14861056 (-)
BALB/cJ MGP_BALBcJ_G0024939
 protein coding gene Chr19:14299102-14335296 (-)
C3H/HeJ MGP_C3HHeJ_G0024697
 protein coding gene Chr19:14771892-14805433 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025381
 protein coding gene Chr19:15705099-15739963 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022800
 protein coding gene Chr19:14684904-14723131 (-)
CAST/EiJ MGP_CASTEiJ_G0024165
 protein coding gene Chr19:14385335-14425742 (-)
CBA/J MGP_CBAJ_G0024675
 protein coding gene Chr19:16238769-16284517 (-)
DBA/2J MGP_DBA2J_G0024807
 protein coding gene Chr19:14296219-14330309 (-)
FVB/NJ MGP_FVBNJ_G0024768
 protein coding gene Chr19:14216133-14249795 (-)
LP/J MGP_LPJ_G0024891
 protein coding gene Chr19:15112818-15146247 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024795
 protein coding gene Chr19:16139211-16172804 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025436
 protein coding gene Chr19:14760453-14796772 (-)
PWK/PhJ MGP_PWKPhJ_G0023914
 protein coding gene Chr19:13827744-13870835 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023719
 protein coding gene Chr19:14059670-14131970 (-)
WSB/EiJ MGP_WSBEiJ_G0024233
 protein coding gene Chr19:14815292-14849402 (-)



Homology
more
  • Human Ortholog
    GCNT1, glucosaminyl (N-acetyl) transferase 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GCNT1, glucosaminyl (N-acetyl) transferase 1
  • Synonyms
    C2GlcNAcT, C2GNT, C2GNT1, C2GNT-L, G6NT, NACGT2, NAGCT2
  • Links
    NCBI Gene ID: 2650
    neXtProt AC: NX_Q02742
    UniProt: Q02742

  • Chr Location
    9q21.13; chr9:76393869-76651203 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this allele display a grossly normal phenotype and are fertile. There are abnormalities in white blood cell counts and in inflammatory response however.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    984
  • Tissues
    180
  • cDNA Data
    13
  • Literature Summary
    6
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14537 NCBI Gene Model | MGI Sequence Detail 46704 C57BL/6J ±  kb
transcript NM_173442 RefSeq | MGI Sequence Detail 4612 ZRU/MplStud  
polypeptide Q09324 UniProt | EBI | MGI Sequence Detail 428 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 5
    cDNA 15
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10022, MGI:1918694
References
more
  • Summaries
    All 84
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 41
  • Earliest
    J:11178 Spies T, et al., Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter [see comments]. Nature. 1991 May 23;351(6324):323-4
  • Latest
    J:305568 Russo AJ, et al., Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin. Nat Immunol. 2021 Feb;22(2):154-165
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory