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Gls Gene Detail
Summary
  • Symbol
    Gls
  • Name
    glutaminase
  • Synonyms
    B230365M23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:95752
    NCBI Gene: 14660
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:52202607-52272391 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 26.86 cM
  • Mapping Data
    23 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1569 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95752
 protein coding gene Chr1:52202607-52274168 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016007
 protein coding gene Chr1:51673367-51743091 (-)
A/J MGP_AJ_G0015989
 protein coding gene Chr1:49943585-50012965 (-)
AKR/J MGP_AKRJ_G0015945
 protein coding gene Chr1:50996317-51067415 (-)
BALB/cJ MGP_BALBcJ_G0015946
 protein coding gene Chr1:49759325-49829145 (-)
C3H/HeJ MGP_C3HHeJ_G0015778
 protein coding gene Chr1:51404778-51476550 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016397
 protein coding gene Chr1:53844333-53930651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014127
 protein coding gene Chr1:41843246-41913074 (+)
CAST/EiJ MGP_CASTEiJ_G0015359
 protein coding gene Chr1:50883414-50954625 (-)
CBA/J MGP_CBAJ_G0015749
 protein coding gene Chr1:55279312-55357715 (-)
DBA/2J MGP_DBA2J_G0015850
 protein coding gene Chr1:49195146-49264685 (-)
FVB/NJ MGP_FVBNJ_G0015852
 protein coding gene Chr1:48659895-48730980 (-)
LP/J MGP_LPJ_G0015921
 protein coding gene Chr1:52168861-52241042 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015872
 protein coding gene Chr1:58307146-58413265 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016445
 protein coding gene Chr1:51128884-51200578 (-)
PWK/PhJ MGP_PWKPhJ_G0015145
 protein coding gene Chr1:49076483-49147944 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014925
 protein coding gene Chr1:50781744-50855311 (-)
WSB/EiJ MGP_WSBEiJ_G0015422
 protein coding gene Chr1:50938562-51010614 (-)



Homology
more
  • Human Ortholog
    GLS, glutaminase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLS, glutaminase
  • Synonyms
    AAD20, CASGID, DEE71, EIEE71, GAC, GAM, GDPAG, GLS1, KGA
  • Links
    NCBI Gene ID: 2744
    neXtProt AC: NX_O94925
    UniProt: O94925

  • Chr Location
    2q32.2; chr2:190880821-190965552 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GLS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 4 alleles in 5 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die within 1 day postnatally with abnormal respiratory function and goal-oriented behavior toward dam. Mice homozygous for another allele exhibit abnormal TNFA-stimulated astrocyte extracellular vesicle release.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    824
  • Tissues
    107
  • cDNA Data
    212
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026103 Ensembl Gene Model | MGI Sequence Detail 69785 C57BL/6J ±  kb
transcript ENSMUST00000114513 Ensembl | MGI Sequence Detail 4966 Not Applicable  
polypeptide ENSMUSP00000110158 Ensembl | MGI Sequence Detail 674 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 224
    Genomic 4
    cDNA 214
    Primer pair 5
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10135, MGI:2138193, MGI:2444416
References
more
  • Summaries
    All 103
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 40
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:358517 Li M, et al., AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res. 2024 Oct;34(10):683-706
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory