About   Help   FAQ
Slc2a1 Gene Detail
Summary
  • Symbol
    Slc2a1
  • Name
    solute carrier family 2 (facilitated glucose transporter), member 1
  • Synonyms
    Glut-1, Glut1, M100200, Rgsc200
  • Feature Type
    protein coding gene
  • IDs
    MGI:95755
    NCBI Gene: 20525
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:118966001-118994527 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4,
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    837 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95755
 protein coding gene Chr4:118965908-118995180 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028687
 protein coding gene Chr4:120287583-120317096 (+)
A/J MGP_AJ_G0028647
 protein coding gene Chr4:115562526-115591790 (+)
AKR/J MGP_AKRJ_G0028600
 protein coding gene Chr4:118071842-118101102 (+)
BALB/cJ MGP_BALBcJ_G0028670
 protein coding gene Chr4:116177356-116207483 (+)
C3H/HeJ MGP_C3HHeJ_G0028385
 protein coding gene Chr4:119635843-119665081 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029111
 protein coding gene Chr4:124860054-124889326 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026388
 protein coding gene Chr4:109662542-109692197 (+)
CAST/EiJ MGP_CASTEiJ_G0027816
 protein coding gene Chr4:116951653-116980957 (+)
CBA/J MGP_CBAJ_G0028352
 protein coding gene Chr4:128223263-128252477 (+)
DBA/2J MGP_DBA2J_G0028499
 protein coding gene Chr4:116153103-116182383 (+)
FVB/NJ MGP_FVBNJ_G0028465
 protein coding gene Chr4:114665564-114695069 (+)
LP/J MGP_LPJ_G0028599
 protein coding gene Chr4:120395931-120425146 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028493
 protein coding gene Chr4:133103225-133132508 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029148
 protein coding gene Chr4:119146156-119175407 (+)
PWK/PhJ MGP_PWKPhJ_G0027539
 protein coding gene Chr4:113072834-113102262 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027365
 protein coding gene Chr4:115560296-115594299 (+)
WSB/EiJ MGP_WSBEiJ_G0027896
 protein coding gene Chr4:119144548-119173785 (+)



Homology
more
  • Human Ortholog
    SLC2A1, solute carrier family 2 member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC2A1, solute carrier family 2 member 1
  • Synonyms
    CSE, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT-1, GLUT1, GLUT1DS, HTLVR, PED, SDCHCN
  • Links
    NCBI Gene ID: 6513
    neXtProt AC: NX_P11166
    UniProt: P11166

  • Chr Location
    1p34.2; chr1:42925353-42958893 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc2a1 mouse models; 9 with human SLC2A1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 3 alleles in 6 genetic backgrounds
    1 images
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos are small, lack visibly detectable eyes, show a diminutive rostral embryonic pole and an overall developmental delay, and die at E10-E14. Heterozygotes show spontaneous seizures, impaired motor performance, hypoglycorrhachia, microencephaly, and reduced brain glucose uptake. Mice homozygous for the p.P485L mutation die immediately after birth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1345
  • Tissues
    174
  • cDNA Data
    310
  • Literature Summary
    153
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20525 NCBI Gene Model | MGI Sequence Detail 28527 C57BL/6J ±  kb
    transcript NM_001424864 RefSeq | MGI Sequence Detail 2628 C57BL/6  
    polypeptide P17809 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000015058 solute carrier family 2, facilitated glucose transporter member 1
      (term hierarchy)
    • InterPro Domains
      IPR045263 Glucose transporter GLUT
      IPR002439 Glucose transporter, type 1 (GLUT1)
      IPR005828 Major facilitator, sugar transporter-like
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR003663 Sugar/inositol transporter
      IPR005829 Sugar transporter, conserved site
    • GlyGen
      P17809 2 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 339
      Genomic 3
      cDNA 314
      Primer pair 19
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10155, MGD-MRK-10159, MGI:3811854
    References
    more
    • Summaries
      All 363
      Developmental Gene Expression 153
      Diseases 1
      Gene Ontology 22
      Phenotypes 63
    • Earliest
      J:16692 Kaestner KH, et al., Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes [published erratum appears in Proc Natl Acad Sci U S A 1989 Jul;86(13):4937]. Proc Natl Acad Sci U S A. 1989 May;86(9):3150-4
    • Latest
      J:357419 Ardanaz CG, et al., Astrocytic GLUT1 reduction paradoxically improves central and peripheral glucose homeostasis. Sci Adv. 2024 Oct 18;10(42):eadp1115
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory