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Slc6a9 Gene Detail
Summary
  • Symbol
    Slc6a9
  • Name
    solute carrier family 6 (neurotransmitter transporter, glycine), member 9
  • Synonyms
    Glyt-1, Glyt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95760
    NCBI Gene: 14664
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117692240-117726502 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    827 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95760
 protein coding gene Chr4:117691703-117732395 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028655
 protein coding gene Chr4:118837095-118878396 (+)
A/J MGP_AJ_G0028616
 protein coding gene Chr4:114252284-114292498 (+)
AKR/J MGP_AKRJ_G0028566
 protein coding gene Chr4:116756389-116799349 (+)
BALB/cJ MGP_BALBcJ_G0028637
 protein coding gene Chr4:114887750-114931220 (+)
C3H/HeJ MGP_C3HHeJ_G0028351
 protein coding gene Chr4:118334018-118374325 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029078
 protein coding gene Chr4:123416614-123457847 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026362
 protein coding gene Chr4:108280237-108321149 (+)
CAST/EiJ MGP_CASTEiJ_G0027785
 protein coding gene Chr4:115559647-115600971 (+)
CBA/J MGP_CBAJ_G0028318
 protein coding gene Chr4:126785199-126825820 (+)
DBA/2J MGP_DBA2J_G0028466
 protein coding gene Chr4:114869675-114910307 (+)
FVB/NJ MGP_FVBNJ_G0028434
 protein coding gene Chr4:113383644-113424916 (+)
LP/J MGP_LPJ_G0028568
 protein coding gene Chr4:119023226-119066580 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028461
 protein coding gene Chr4:131704241-131746904 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029115
 protein coding gene Chr4:117898999-117940525 (+)
PWK/PhJ MGP_PWKPhJ_G0027511
 protein coding gene Chr4:111690000-111730420 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027334
 protein coding gene Chr4:114216180-114258090 (+)
WSB/EiJ MGP_WSBEiJ_G0027864
 protein coding gene Chr4:117783923-117825149 (+)



Homology
more
  • Human Ortholog
    SLC6A9, solute carrier family 6 member 9
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC6A9, solute carrier family 6 member 9
  • Synonyms
    GCENSG, GLYT1
  • Links
    NCBI Gene ID: 6536
    neXtProt AC: NX_P48067
    UniProt: P48067

  • Chr Location
    1p34.1; chr1:43991500-44031467 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc6a9 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 6 alleles in 7 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die shortly after birth exhibiting breathing and movement deficiencies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1043
  • Tissues
    158
  • cDNA Data
    16
  • Literature Summary
    49
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14664 NCBI Gene Model | MGI Sequence Detail 34263 C57BL/6J ±  kb
    transcript NM_008135 RefSeq | MGI Sequence Detail 3272 Not Specified  
    polypeptide P28571 UniProt | EBI | MGI Sequence Detail 692 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000015193 sodium- and chloride-dependent glycine transporter 1
      (term hierarchy)
    • InterPro Domains
      IPR000175 Sodium:neurotransmitter symporter
      IPR003028 Sodium:neurotransmitter symporter, glycine, type 1
      IPR037272 Sodium:neurotransmitter symporter superfamily
    • GlyGen
      P28571 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 28
      Genomic 5
      cDNA 20
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-10166, MGD-MRK-10167
    References
    more
    • Summaries
      All 110
      Developmental Gene Expression 49
      Diseases 1
      Gene Ontology 10
      Phenotypes 29
    • Earliest
      J:1378 Liu QR, et al., Cloning and expression of a glycine transporter from mouse brain. FEBS Lett. 1992 Jun 29;305(2):110-4
    • Latest
      J:354849 Wutikeli H, et al., Role of Elavl-like RNA-binding protein in retinal development and signal transduction. Biochim Biophys Acta Mol Basis Dis. 2024 Sep 20;1871(1):167518
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory