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Gnao1 Gene Detail
Summary
  • Symbol
    Gnao1
  • Name
    guanine nucleotide binding protein, alpha O
  • Synonyms
    alphaO, Galphao, GO, Go alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95775
    NCBI Gene: 14681
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94537213-94696016 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 45.94 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3985 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95775
 protein coding gene Chr8:94536594-94696016 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033949
 protein coding gene Chr8:95192618-95356401 (+)
A/J MGP_AJ_G0033932
 protein coding gene Chr8:91484226-91648866 (+)
AKR/J MGP_AKRJ_G0033858
 protein coding gene Chr8:94005505-94168798 (+)
BALB/cJ MGP_BALBcJ_G0033924
 protein coding gene Chr8:91577653-91738300 (+)
C3H/HeJ MGP_C3HHeJ_G0033634
 protein coding gene Chr8:94702308-94867172 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034445
 protein coding gene Chr8:98680760-98844837 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031386
 protein coding gene Chr8:85294166-85450613 (+)
CAST/EiJ MGP_CASTEiJ_G0032966
 protein coding gene Chr8:94264160-94430199 (+)
CBA/J MGP_CBAJ_G0033610
 protein coding gene Chr8:101955407-102131532 (+)
DBA/2J MGP_DBA2J_G0033764
 protein coding gene Chr8:90956430-91115212 (+)
FVB/NJ MGP_FVBNJ_G0033711
 protein coding gene Chr8:89919947-90083951 (+)
LP/J MGP_LPJ_G0033856
 protein coding gene Chr8:95340388-95504023 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033753
 protein coding gene Chr8:104247426-104414076 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034463
 protein coding gene Chr8:94152843-94314550 (+)
PWK/PhJ MGP_PWKPhJ_G0032668
 protein coding gene Chr8:90311399-90473866 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032505
 protein coding gene Chr8:92974117-93134111 (+)
WSB/EiJ MGP_WSBEiJ_G0033078
 protein coding gene Chr8:94581260-94746630 (+)



Homology
more
  • Human Ortholog
    GNAO1, G protein subunit alpha o1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNAO1, G protein subunit alpha o1
  • Synonyms
    DEE17, EIEE17, G-ALPHA-o, GNAO, HG1G, HLA-DQB1, NEDIM
  • Links
    NCBI Gene ID: 2775
    neXtProt AC: NX_P09471
    UniProt: P09471

  • Chr Location
    16q13; chr16:56189660-56357444 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with Gnao1 mouse models; 2 with human GNAO1 associations

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    71 phenotypes from 13 alleles in 15 genetic backgrounds
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice lacking both isoforms exhibit reduced survival, sterility, low body weight, hyperalgesia, tremors, turning behavior, impaired locomotion, altered channel response and improved glucose tolerance. Isoform-specific deletion may lead to increased insulin release and abnormal eye electrophysiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1196
  • Tissues
    262
  • cDNA Data
    176
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14681 NCBI Gene Model | MGI Sequence Detail 158804 C57BL/6J ±  kb
    transcript NR_188943 RefSeq | MGI Sequence Detail 6375 C57BL/6  
    polypeptide P18872 UniProt | EBI | MGI Sequence Detail 354 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008089 guanine nucleotide-binding protein G(o) subunit alpha
      (term hierarchy)
    • PDB
      3C7K
    • EC
      3.6.5.-
    • InterPro Domains
      IPR001408 G-protein alpha subunit, group I
      IPR011025 G protein alpha subunit, helical insertion
      IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      P18872 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 189
      Genomic 1
      cDNA 178
      Primer pair 5
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10187, MGI:2142753
    References
    more
    • Summaries
      All 154
      Developmental Gene Expression 44
      Diseases 3
      Gene Ontology 20
      Phenotypes 57
    • Earliest
      J:31017 Itoh H, et al., Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A. 1986 Jun;83(11):3776-80
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory