About   Help   FAQ
Gnb2 Gene Detail
Summary
  • Symbol
    Gnb2
  • Name
    guanine nucleotide binding protein (G protein), beta 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95784
    NCBI Gene: 14693
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:137526389-137531772 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.54 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95784
 protein coding gene Chr5:137526389-137533085 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030230
 protein coding gene Chr5:142293822-142301266 (-)
A/J MGP_AJ_G0030198
 protein coding gene Chr5:136089158-136094214 (-)
AKR/J MGP_AKRJ_G0030131
 protein coding gene Chr5:140510533-140515590 (-)
BALB/cJ MGP_BALBcJ_G0030208
 protein coding gene Chr5:137458671-137463812 (-)
C3H/HeJ MGP_C3HHeJ_G0029924
 protein coding gene Chr5:141159910-141164963 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030660
 protein coding gene Chr5:147553756-147558857 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027878
 protein coding gene Chr5:130331556-130336698 (-)
CAST/EiJ MGP_CASTEiJ_G0029334
 protein coding gene Chr5:140564721-140570918 (-)
CBA/J MGP_CBAJ_G0029894
 protein coding gene Chr5:153419352-153426715 (-)
DBA/2J MGP_DBA2J_G0030045
 protein coding gene Chr5:135992561-135997660 (-)
FVB/NJ MGP_FVBNJ_G0030000
 protein coding gene Chr5:135201743-135206891 (-)
LP/J MGP_LPJ_G0030134
 protein coding gene Chr5:142753775-142758898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030032
 protein coding gene Chr5:156245870-156252026 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030701
 protein coding gene Chr5:140363914-140368804 (-)
PWK/PhJ MGP_PWKPhJ_G0029047
 protein coding gene Chr5:135079453-135084818 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028883
 protein coding gene Chr5:137926170-137931341 (-)
WSB/EiJ MGP_WSBEiJ_G0029407
 protein coding gene Chr5:141090675-141095977 (-)



Homology
more
  • Human Ortholog
    GNB2, G protein subunit beta 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GNB2, G protein subunit beta 2
  • Synonyms
    HG2C1, SSS4, SSS4; NEDHYDF
  • Links
    NCBI Gene ID: 2783
    neXtProt AC: NX_P62879
    UniProt: P62879

  • Chr Location
    7q22.1; chr7:100673567-100679174 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    762
  • Tissues
    39
  • cDNA Data
    369
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029713 Ensembl Gene Model | MGI Sequence Detail 5384 C57BL/6J ±  kb
    transcript ENSMUST00000111027 Ensembl | MGI Sequence Detail 1610 Not Applicable  
    polypeptide ENSMUSP00000106656 Ensembl | MGI Sequence Detail 382 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000008097 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
      (term hierarchy)
    • InterPro Domains
      IPR001632 G-protein, beta subunit
      IPR020472 G-protein beta WD-40 repeat
      IPR016346 Guanine nucleotide-binding protein, beta subunit
      IPR001680 WD40 repeat
      IPR019775 WD40 repeat, conserved site
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      P62880 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 378
      Genomic 1
      cDNA 371
      Primer pair 5
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10197, MGD-MRK-10203
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 10
    • Earliest
      J:31005 Fong HK, et al., Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. Proc Natl Acad Sci U S A. 1987 Jun;84(11):3792-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory