Grin2a MGI Mouse Gene Detail - MGI:95820 - glutamate receptor, ionotropic, NMDA2A (epsilon 1)

Symbol

Grin2a
Name

glutamate receptor, ionotropic, NMDA2A (epsilon 1)
Synonyms

GluN2A, GluRepsilon1, NMDAR2A, NR2A

Feature Type

protein coding gene
IDs

MGI:95820
NCBI Gene: 14811
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr16:9385762-9813424 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 5.28 cM
Mapping Data

2 experiments

SNPs within 2kb

11499 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95820	protein coding gene	Chr16:9385762-9813744 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022501	protein coding gene	Chr16:6305626-6748053 (-)
A/J	MGP_AJ_G0022463	protein coding gene	Chr16:5962515-6391998 (-)
AKR/J	MGP_AKRJ_G0022439	protein coding gene	Chr16:6261541-6707383 (-)
BALB/cJ	MGP_BALBcJ_G0022467	protein coding gene	Chr16:6094349-6523676 (-)
C3H/HeJ	MGP_C3HHeJ_G0022234	protein coding gene	Chr16:6299422-6742563 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022916	protein coding gene	Chr16:6456750-6911800 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020437	protein coding gene	Chr16:6126339-6536053 (-)
CAST/EiJ	MGP_CASTEiJ_G0021761	protein coding gene	Chr16:6331256-6767314 (-)
CBA/J	MGP_CBAJ_G0022203	protein coding gene	Chr16:6718592-7176741 (-)
DBA/2J	MGP_DBA2J_G0022334	protein coding gene	Chr16:5975263-6404572 (-)
FVB/NJ	MGP_FVBNJ_G0022310	protein coding gene	Chr16:5960675-6391122 (-)
LP/J	MGP_LPJ_G0022402	protein coding gene	Chr16:6274580-6716481 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022332	protein coding gene	Chr16:6472102-6914436 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022929	protein coding gene	Chr16:6203682-6650024 (-)
PWK/PhJ	MGP_PWKPhJ_G0021501	protein coding gene	Chr16:6174187-6598550 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021331	protein coding gene	Chr16:6262394-6710254 (-)
WSB/EiJ	MGP_WSBEiJ_G0021809	protein coding gene	Chr16:6241951-6695669 (-)

Human Ortholog

GRIN2A, glutamate ionotropic receptor NMDA type subunit 2A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GRIN2A, glutamate ionotropic receptor NMDA type subunit 2A
Synonyms

EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
Links

HGNC:4585

NCBI Gene ID: 2903

neXtProt AC: NX_Q12879

UniProt: Q12879
Chr Location

16p13.2; chr16:9753404-10182928 (-) GRCh38

MGI Vertebrate Homology

Grin2a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GRIN2A
Gene Tree

Grin2a

Diseases

6 with human GRIN2A associations

				Human Disease	Mouse Models
				alcohol dependence IDs alcohol dependence DOID:0050741 KEGG:05034 OMIM:103780
				bipolar disorder IDs bipolar disorder DOID:3312 DOID:3311 DOID:9554 DOID:9555 ICD10CM:F31 ICD9CM:296.40 ICD9CM:296.60 ICD9CM:296.80 MESH:D001714 NCI:C34423 NCI:C34424 NCI:C34805 UMLS_CUI:C0005586 UMLS_CUI:C0005587 UMLS_CUI:C0024713 UMLS_CUI:C0236780
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				heroin dependence IDs heroin dependence DOID:9976 MESH:D006556 NCI:C34694 UMLS_CUI:C0019337
				Huntington's disease IDs Huntington's disease DOID:12858 ICD10CM:G10 ICD9CM_2006:333.4 ICD9CM:333.4 KEGG:05016 MESH:D006816 NCI:C82342 OMIM:143100 UMLS_CUI:C0020179
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

23 phenotypes from 7 alleles in 8 genetic backgrounds
10 phenotypes from multigenic genotypes
126 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Endonuclease-mediated

6
Targeted

13
Transgenic

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

66 strains or lines available

Homozygotes for targeted null mutations exhibit jumpiness, mildly impaired long-term potentiation and spatial learning, increased locomotor activity and metabolism of dopamine and serotonin, and loss of analgesic tolerance after repeated morphine doses.

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All GO Annotations

180
GO References

75

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

993
Tissues

99
cDNA Data

8
Literature Summary

48

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GRIN2A

ZFIN grin2aa

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All Sequences

36
RefSeq

4
UniProt

1
CCDS

CCDS27943.1

Ensembl

ENSMUSG00000059003 (Evidence)
NCBI Gene

14811

			Length	Strain/Species	Flank
genomic	ENSMUSG00000059003	Ensembl Gene Model \| MGI Sequence Detail	427663	C57BL/6J	± kb
transcript	ENSMUST00000032331	Ensembl \| MGI Sequence Detail	4395	Not Applicable
polypeptide	ENSMUSP00000032331	Ensembl \| MGI Sequence Detail	1464	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000008246 glutamate receptor ionotropic, NMDA 2A

(term hierarchy)
InterPro Domains

IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal

IPR015683 Ionotropic glutamate receptor

IPR001320 Ionotropic glutamate receptor, C-terminal

IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IPR001508 Ionotropic glutamate receptor, metazoa

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region
GlyGen

P35436 11 sites, 8 N-linked glycans (9 sites)

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All nucleic 24

Genomic 3

cDNA 10

Primer pair 2

Other 9

Microarray probesets 3

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MGD-MRK-10258

Summaries

All 316

Developmental Gene Expression 48

Gene Ontology 75

Phenotypes 126
Earliest

J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
Latest

J:346087 Lu Y, et al., Differential depletion of GluN2A induces heterogeneous schizophrenia-related phenotypes in mice. EBioMedicine. 2024 Mar 11;102:105045

TSS for Grin2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139906	Chr16:9813670-9813682 (-)	-252 bp
Tssr139905	Chr16:9813565-9813589 (-)	-153 bp
Tssr139904	Chr16:9813492-9813533 (-)	-89 bp
Tssr139903	Chr16:9813426-9813445 (-)	-12 bp
Tssr139902	Chr16:9813390-9813413 (-)	22 bp
Tssr139901	Chr16:9813372-9813383 (-)	46 bp
Tssr139900	Chr16:9813276-9813307 (-)	132 bp
Tssr139899	Chr16:9813242-9813264 (-)	171 bp
Tssr139898	Chr16:9813212-9813236 (-)	200 bp
Tssr139897	Chr16:9813179-9813207 (-)	231 bp
Tssr139896	Chr16:9813163-9813168 (-)	258 bp
Tssr139895	Chr16:9812908-9812952 (-)	494 bp
Tssr139894	Chr16:9812864-9812876 (-)	554 bp
Tssr139893	Chr16:9812411-9812431 (-)	1,003 bp
Tssr4788	Chr16:9785353-9785365 (-)	28,065 bp
Tssr139892	Chr16:9785318-9785329 (-)	28,100 bp
Tssr139891	Chr16:9739020-9739038 (-)	74,395 bp
Tssr139890	Chr16:9737662-9737674 (-)	75,756 bp
Tssr139889	Chr16:9737619-9737632 (-)	75,798 bp
Tssr139888	Chr16:9712893-9712907 (-)	100,524 bp
Tssr139887	Chr16:9389833-9389834 (-)	423,590 bp
Tssr139886	Chr16:9388851-9388858 (-)	424,569 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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