| Human Disease | Mouse Models | ||||
|---|---|---|---|---|---|
|
IDs
|
early conceptus |
embryo ectoderm |
embryo endoderm |
embryo mesoderm |
embryo mesenchyme |
extraembryonic component |
alimentary system |
auditory system |
branchial arches |
cardiovascular system |
connective tissue |
endocrine system |
exocrine system |
hemolymphoid system |
integumental system |
limbs |
liver and biliary system |
musculoskeletal system |
nervous system |
olfactory system |
reproductive system |
respiratory system |
urinary system |
visual system |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Transcription Start Site | Location | Distance from Gene 5'-end |
| Tssr17413 | Chr2:34662101-34662106 (+) | 2 bp |
| Tssr17414 | Chr2:34662594-34662627 (+) | 509 bp |
| Tssr17415 | Chr2:34662701-34662775 (+) | 636 bp |
| Tssr473 | Chr2:34664032-34664060 (+) | 1,944 bp |
| Tssr17416 | Chr2:34664192-34664228 (+) | 2,108 bp |
| Tssr17417 | Chr2:34664370-34664402 (+) | 2,284 bp |
| Tssr17418 | Chr2:34664670-34664681 (+) | 2,574 bp |
| Tssr17419 | Chr2:34664692-34664758 (+) | 2,623 bp |
| Tssr17420 | Chr2:34665127-34665148 (+) | 3,036 bp |
| Tssr17421 | Chr2:34665155-34665211 (+) | 3,081 bp |
| Tssr17422 | Chr2:34665545-34665590 (+) | 3,466 bp |
| Tssr17423 | Chr2:34665593-34665605 (+) | 3,497 bp |
| Tssr17424 | Chr2:34665607-34665657 (+) | 3,530 bp |
| Tssr17425 | Chr2:34665731-34665760 (+) | 3,644 bp |
| Tssr17426 | Chr2:34665770-34665793 (+) | 3,680 bp |
| Tssr17427 | Chr2:34665799-34665834 (+) | 3,715 bp |
| Tssr17428 | Chr2:34665897-34665984 (+) | 3,839 bp |
| Tssr17429 | Chr2:34666281-34666289 (+) | 4,183 bp |
| QTL | Genetic Location* | Genome Location (GRCm39) | Reference | QTL Note |
| Actre2 | Chr2, 57.65 cM | Chr2:80005954-80006113 | J:98595 | Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot). |
| Actre3 | Chr2, 68.30 cM | Chr2:112024987-128173821 | J:98595 | Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot). |
| Actre4 | Chr2, 59.40 cM | Chr2:112024987-128173821 | J:98595 | Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot). |
| Alcp1 | Chr2, 27.37 cM | Chr2:45228128-67838868 | J:98595 | Microarray analysis was used to identify genes showing alcohol-induced differential expression between inbred strains C57BL/6J and DBA/2J. These genes were then correlated to alcohol-related QTLs to identify potential candidate genes. The experiment involved identifying genes expressed differentially in alcohol-induced and non-induced animals but the following list of candidate genes are only for alcohol-induced states. On mouse Chromosome 2, several candidate genes were identified for Actre2 at 48 cM,Actre3 at 63 cM, Actre4 at 65 cM, and Alcp1 at 37 cM. Candidate genes for Actre2 are Dlx1 (44 cM), Frzb (49.75 cM), D2Ertd391e, and Kai1 (49.6 cM). Candidate genes for Actre3 and Actre4 are Bdnf (62 cM) and Actc1 (64 cM), respectively. Candidate genes forAlcp1 are Pbx3 (22 cM), Hspa5 (22.5 cM), Rprm, Pkp4, and March7 (formerly Axot). |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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