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H19 Gene Detail
Summary
  • Symbol
    H19
  • Name
    H19, imprinted maternally expressed transcript
  • Feature Type
    lncRNA gene
  • IDs
    MGI:95891
    NCBI Gene: 14955
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:142129267-142131883 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 87.97 cM
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    93 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95891
 lncRNA gene Chr7:142129262-142131917 (-)
129S1/SvImJ MGP_129S1SvImJ_G0007295
 lincRNA gene Chr7:147836487-147839081 (-)
A/J MGP_AJ_G0007292
 lincRNA gene Chr7:143570668-143573282 (-)
AKR/J MGP_AKRJ_G0007262
 lincRNA gene Chr7:147595973-147598587 (-)
BALB/cJ MGP_BALBcJ_G0007270
 lincRNA gene Chr7:143340224-143343501 (-)
C3H/HeJ MGP_C3HHeJ_G0007214
 lincRNA gene Chr7:147359120-147361746 (-)
C57BL/6NJ MGP_C57BL6NJ_G0007440
 lincRNA gene Chr7:153178758-153184004 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0006643
 lincRNA gene Chr7:144776697-144779312 (-)
CAST/EiJ MGP_CASTEiJ_G0007116
 lincRNA gene Chr7:139668992-139673525 (-)
CBA/J MGP_CBAJ_G0007197
 lincRNA gene Chr7:158429185-158434178 (-)
DBA/2J MGP_DBA2J_G0007218
 lincRNA gene Chr7:141521247-141523858 (-)
FVB/NJ MGP_FVBNJ_G0007240
 lincRNA gene Chr7:141459246-141461669 (-)
LP/J MGP_LPJ_G0007300
 lincRNA gene Chr7:149345496-149349414 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0007217
 lincRNA gene Chr7:159043748-159047848 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0007443
 lincRNA gene Chr7:146545731-146548355 (-)
PWK/PhJ MGP_PWKPhJ_G0007058
 lincRNA gene Chr7:134849455-134852262 (-)
SPRET/EiJ MGP_SPRETEiJ_G0006966
 lincRNA gene Chr7:133344048-133346643 (-)
WSB/EiJ MGP_WSBEiJ_G0007176
 lincRNA gene Chr7:147527926-147533444 (-)



Homology
less
  • Gene Tree
    H19
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 7 alleles in 9 genetic backgrounds
    21 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased body weight. Mice heterozygous for a maternally inherited knock-out allele exhibit increased placenta and body weight. Mice heterozygous for a different knock-out allele paternally inherited exhibit decreased fetal and postnatal body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    10
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1457
  • Tissues
    239
  • cDNA Data
    37
  • Literature Summary
    151
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      62
    • RefSeq
      2
    • UniProt
      2
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14955 NCBI Gene Model | MGI Sequence Detail 2617 C57BL/6J ±  kb
    transcript NR_130973 RefSeq | MGI Sequence Detail 2288 ZRU/MplStud  
    polypeptide Q61639 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    Molecular
    Reagents
    less
    • All nucleic 152
      Genomic 47
      cDNA 44
      Primer pair 39
      Other 22

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10486, MGI:2142026
    References
    more
    • Summaries
      All 383
      Developmental Gene Expression 151
      Diseases 1
      Gene Ontology 6
      Phenotypes 56
    • Earliest
      J:20185 Crouse HV, The controlling element in sex chromosome behavior in Sciara. Genetics. 1960;45(10):1425-43
    • Latest
      J:354592 Sandovici I, et al., Overexpression of Igf2-derived Mir483 inhibits Igf1 expression and leads to developmental growth restriction and metabolic dysfunction in mice. Cell Rep. 2024 Sep 24;43(9):114750
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory