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H2-M2 Gene Detail
Summary
  • Symbol
    H2-M2
  • Name
    histocompatibility 2, M region locus 2
  • Synonyms
    H-2M2, Thy19.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95914
    NCBI Gene: 14990
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37791742-37794443 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • Strain Annotations
    17
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95914
 protein coding gene Chr17:37791742-37794445 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023714
 protein coding gene Chr17:37887793-37890489 (-)
A/J MGP_AJ_G0023672
 protein coding gene Chr17:36722826-36725527 (-)
AKR/J MGP_AKRJ_G0023643
 protein coding gene Chr17:37144109-37146819 (-)
BALB/cJ MGP_BALBcJ_G0023678
 protein coding gene Chr17:36936001-36938709 (-)
C3H/HeJ MGP_C3HHeJ_G0023440
 protein coding gene Chr17:37685984-37688694 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024116
 protein coding gene Chr17:39504762-39507463 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0022926
 protein coding gene Chr17:37770808-37773584 (-)
CBA/J MGP_CBAJ_G0023417
 protein coding gene Chr17:41063223-41065933 (-)
DBA/2J MGP_DBA2J_G0023543
 protein coding gene Chr17:36066085-36068789 (-)
FVB/NJ MGP_FVBNJ_G0023516
 protein coding gene Chr17:35683159-35685859 (-)
LP/J MGP_LPJ_G0023621
 protein coding gene Chr17:38455166-38457842 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023539
 protein coding gene Chr17:39861667-39864368 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024162
 protein coding gene Chr17:37493062-37495766 (-)
PWK/PhJ MGP_PWKPhJ_G0022673
 protein coding gene Chr17:34843466-34846273 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022494
 protein coding gene Chr17:35570121-35573248 (-)
WSB/EiJ MGP_WSBEiJ_G0022990
 protein coding gene Chr17:37837148-37839822 (-)



Homology
more
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Vertebrate Orthologs
    13
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Synonyms
    AS, B-4901, HLAB
  • Links
    NCBI Gene ID: 3106
    neXtProt AC: NX_P01889
    UniProt: P01889

  • Chr Location
    6p21.33; chr6:31353872-31367067 (-)  GRCh38
  • Human Ortholog
    HLA-C, major histocompatibility complex, class I, C
  • Synonyms
    D6S204, HLAC, HLA-JY3, HLC-C, MHC, PSORS1
  • Links
    NCBI Gene ID: 3107
    neXtProt AC: NX_P10321
    UniProt: P10321

  • Chr Location
    6p21.33; chr6:31268749-31272130 (-)  GRCh38
  • Human Ortholog
    HLA-E, major histocompatibility complex, class I, E
  • Synonyms
    HLA-6.2, QA1
  • Links
    NCBI Gene ID: 3133
    neXtProt AC: NX_P13747
    UniProt: P13747

  • Chr Location
    6p22.1; chr6:30489509-30494194 (+)  GRCh38
  • Human Ortholog
    HLA-F, major histocompatibility complex, class I, F
  • Synonyms
    CDA12, HLA-5.4, HLA-CDA12, HLAF
  • Links
    NCBI Gene ID: 3134
    neXtProt AC: NX_P30511
    UniProt: P30511

  • Chr Location
    6p22.1; chr6:29722775-29738532 (+)  GRCh38
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
  • Synonyms
    MHC-G
  • Links
    NCBI Gene ID: 3135
    neXtProt AC: NX_P17693
    UniProt: P17693

  • Chr Location
    6p22.1; chr6:29826474-29831125 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype reference
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    739
  • Tissues
    24
  • cDNA Data
    6
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016283 Ensembl Gene Model | MGI Sequence Detail 2702 C57BL/6J ±  kb
transcript ENSMUST00000171139 Ensembl | MGI Sequence Detail 1298 Not Applicable  
polypeptide ENSMUSP00000131297 Ensembl | MGI Sequence Detail 343 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    Q6W9L1 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
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  • All nucleic 23
    Genomic 9
    cDNA 6
    Primer pair 1
    Other 7

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-10399, MGD-MRK-10510, MGD-MRK-15103
References
more
  • Summaries
    All 31
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 1
  • Earliest
    J:10054 Brorson KA, et al., Analysis of a new class I gene mapping to the Hmt region of the mouse. Immunogenetics. 1989;30(4):273-83
  • Latest
    J:327971 Frederico B, et al., DNGR-1-tracing marks an ependymal cell subset with damage-responsive neural stem cell potential. Dev Cell. 2022 Aug 22;57(16):1957-1975.e9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory