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H2-M3 Gene Detail
Summary
  • Symbol
    H2-M3
  • Name
    histocompatibility 2, M region locus 3
  • Synonyms
    H-2M3, Hmt, R4B2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95915
    NCBI Gene: 14991
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:37581111-37585375 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 19.16 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95915
 protein coding gene Chr17:37581094-37585380 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023706
 protein coding gene Chr17:37648165-37652451 (+)
A/J MGP_AJ_G0023664
 protein coding gene Chr17:36501978-36506242 (+)
AKR/J MGP_AKRJ_G0023635
 protein coding gene Chr17:36904650-36908936 (+)
BALB/cJ MGP_BALBcJ_G0023670
 protein coding gene Chr17:36714666-36718930 (+)
C3H/HeJ MGP_C3HHeJ_G0023433
 protein coding gene Chr17:37453379-37457665 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024108
 protein coding gene Chr17:39286750-39291014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021577
 protein coding gene Chr17:34268685-34272985 (+)
CAST/EiJ MGP_CASTEiJ_G0022918
 protein coding gene Chr17:37577105-37581370 (+)
CBA/J MGP_CBAJ_G0023410
 protein coding gene Chr17:40834422-40838708 (+)
DBA/2J MGP_DBA2J_G0023535
 protein coding gene Chr17:35863619-35867883 (+)
FVB/NJ MGP_FVBNJ_G0023508
 protein coding gene Chr17:35474325-35478589 (+)
LP/J MGP_LPJ_G0023613
 protein coding gene Chr17:38209610-38213906 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023531
 protein coding gene Chr17:39597923-39602187 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024154
 protein coding gene Chr17:37272710-37276974 (+)
PWK/PhJ MGP_PWKPhJ_G0022665
 protein coding gene Chr17:34636750-34641036 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022487
 protein coding gene Chr17:35358102-35362393 (+)
WSB/EiJ MGP_WSBEiJ_G0022984
 protein coding gene Chr17:37618332-37622618 (+)



Homology
more
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
  • Synonyms
    MHC-G
  • Links
    NCBI Gene ID: 3135
    neXtProt AC: NX_P17693
    UniProt: P17693

  • Chr Location
    6p22.1; chr6:29826474-29831125 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
At least three alleles are known for this locus: allele a, found in C57BL/6, C3H-Pgk1a, NZO and NMRI, and allele c, found in M. spretus determine distinct antigen specificities. Allele b, found in M.m. castaneus results in absence of antigen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    58
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016206 Ensembl Gene Model | MGI Sequence Detail 4265 C57BL/6J ±  kb
transcript ENSMUST00000038580 Ensembl | MGI Sequence Detail 1438 Not Applicable  
polypeptide ENSMUSP00000035687 Ensembl | MGI Sequence Detail 336 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • PDB
    1MHC, 7LFI, 7LFJ, 7LFK, 7LFL, 7LFM
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    Q31093 1 site
Molecular
Reagents
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  • All nucleic 34
    Genomic 13
    cDNA 13
    Primer pair 1
    Other 7

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-10400, MGD-MRK-10511, MGD-MRK-10801
References
more
  • Summaries
    All 57
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:7254 Lindahl KF, et al., A new H-2-linked class I gene whose expression depends on a maternally inherited factor. Nature. 1983 Nov 24-30;306(5941):383-5
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory