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H2-DMa Gene Detail
Summary
  • Symbol
    H2-DMa
  • Name
    histocompatibility 2, class II, locus DMa
  • Synonyms
    H2-Ma, H-2Ma, H2-M alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:95921
    NCBI Gene: 14998
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34338667-34358075 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95921
 protein coding gene Chr17:34338515-34358075 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023558
 protein coding gene Chr17:34117119-34121038 (+)
A/J MGP_AJ_G0023522
 protein coding gene Chr17:32929737-32933652 (+)
AKR/J MGP_AKRJ_G0023485
 protein coding gene Chr17:33359936-33363851 (+)
BALB/cJ MGP_BALBcJ_G0023524
 protein coding gene Chr17:33089927-33106237 (+)
C3H/HeJ MGP_C3HHeJ_G0023285
 protein coding gene Chr17:33688232-33707300 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023965
 protein coding gene Chr17:35416095-35420014 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021443
 protein coding gene Chr17:30466536-30470471 (+)
CAST/EiJ MGP_CASTEiJ_G0022784
 protein coding gene Chr17:33800002-33803921 (+)
CBA/J MGP_CBAJ_G0023262
 protein coding gene Chr17:36812831-36821779 (+)
DBA/2J MGP_DBA2J_G0023393
 protein coding gene Chr17:32312499-32316414 (+)
FVB/NJ MGP_FVBNJ_G0023357
 protein coding gene Chr17:32181776-32185695 (+)
LP/J MGP_LPJ_G0023468
 protein coding gene Chr17:34390155-34394074 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023380
 protein coding gene Chr17:35852939-35856854 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024007
 protein coding gene Chr17:33694817-33698733 (+)
PWK/PhJ MGP_PWKPhJ_G0022534
 protein coding gene Chr17:31240112-31244034 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022349
 protein coding gene Chr17:31644037-31647958 (+)
WSB/EiJ MGP_WSBEiJ_G0022845
 protein coding gene Chr17:33695855-33711722 (+)



Homology
more
  • Human Ortholog
    HLA-DMA, major histocompatibility complex, class II, DM alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DMA, major histocompatibility complex, class II, DM alpha
  • Synonyms
    D6S222E, DMA, HLADM, RING6
  • Links
    NCBI Gene ID: 3108
    UniProt: P28067

  • Chr Location
    6p21.32; chr6:32948613-32969094 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 5 alleles in 7 genetic backgrounds
    8 phenotypes from multigenic genotypes
    72 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired antigen presenting cell function, poor IgG responses to T-dependent antigens, reduced numbers of mature CD4+ T cells, and increased susceptibility to Leishmania major infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    58
  • cDNA Data
    64
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14998 NCBI Gene Model | MGI Sequence Detail 19409 C57BL/6J ±  kb
    transcript NM_001360530 RefSeq | MGI Sequence Detail 2061 ZRU/MplStud  
    polypeptide P28078 UniProt | EBI | MGI Sequence Detail 261 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000033943 class II histocompatibility antigen, M alpha chain
      (term hierarchy)
    • PDB
      1K8I
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR050160 Major Histocompatibility Complex/Immunoglobulin
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR014745 MHC class II, alpha/beta chain, N-terminal
      IPR001003 MHC class II, alpha chain, N-terminal
    • GlyGen
      P28078 2 sites
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 9
      cDNA 65
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10405, MGD-MRK-10517
    References
    more
    • Summaries
      All 114
      Developmental Gene Expression 3
      Gene Ontology 18
      Phenotypes 72
    • Earliest
      J:11259 Cho S, et al., A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5197-201
    • Latest
      J:355301 Zhou X, et al., MHC class II regulation of CD8(+) T cell tolerance and implications in autoimmunity and cancer immunotherapy. Cell Rep. 2023 Nov 28;42(11):113452
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory