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H2-Oa Gene Detail
Summary
  • Symbol
    H2-Oa
  • Name
    histocompatibility 2, O region alpha locus
  • Synonyms
    H-2Oa
  • Feature Type
    protein coding gene
  • IDs
    MGI:95924
    NCBI Gene: 15001
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:34311314-34314208 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 17.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95924
 protein coding gene Chr17:34311314-34314286 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023556
 protein coding gene Chr17:34066260-34069154 (+)
A/J MGP_AJ_G0023520
 protein coding gene Chr17:32884351-32887232 (+)
AKR/J MGP_AKRJ_G0023483
 protein coding gene Chr17:33300892-33303773 (+)
BALB/cJ MGP_BALBcJ_G0023522
 protein coding gene Chr17:33057660-33060553 (+)
C3H/HeJ MGP_C3HHeJ_G0023283
 protein coding gene Chr17:33654965-33657846 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023963
 protein coding gene Chr17:35368377-35371271 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021441
 protein coding gene Chr17:30424261-30427218 (+)
CAST/EiJ MGP_CASTEiJ_G0022782
 protein coding gene Chr17:33754552-33757443 (+)
CBA/J MGP_CBAJ_G0023260
 protein coding gene Chr17:36768455-36771336 (+)
DBA/2J MGP_DBA2J_G0023391
 protein coding gene Chr17:32268340-32271220 (+)
FVB/NJ MGP_FVBNJ_G0023355
 protein coding gene Chr17:32136264-32139400 (+)
LP/J MGP_LPJ_G0023466
 protein coding gene Chr17:34345416-34348310 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023378
 protein coding gene Chr17:35809627-35812520 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024005
 protein coding gene Chr17:33649323-33652216 (+)
PWK/PhJ MGP_PWKPhJ_G0022532
 protein coding gene Chr17:31195725-31198616 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022347
 protein coding gene Chr17:31595244-31599240 (+)
WSB/EiJ MGP_WSBEiJ_G0022843
 protein coding gene Chr17:33658120-33660998 (+)



Homology
more
  • Human Ortholog
    HLA-DOA, major histocompatibility complex, class II, DO alpha
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-DOA, major histocompatibility complex, class II, DO alpha
  • Synonyms
    HLA-DNA, HLADZ, HLA-DZA
  • Links
    NCBI Gene ID: 3111
    neXtProt AC: NX_P06340
    UniProt: P06340

  • Chr Location
    6p21.32; chr6:33004182-33009591 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HLA-DOA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous inactivation of this gene results in abnormal antigen presentation via MHC class II. Mice homozygous for a knock-out allele show enhanced selection of CD4+ single positive thymocytes. Mice homozygous for a different knock-out allele show increased serum IgG1 levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    15
  • cDNA Data
    21
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024334 Ensembl Gene Model | MGI Sequence Detail 2895 C57BL/6J ±  kb
    transcript ENSMUST00000025192 Ensembl | MGI Sequence Detail 1088 Not Applicable  
    polypeptide ENSMUSP00000025192 Ensembl | MGI Sequence Detail 250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR050160 Major Histocompatibility Complex/Immunoglobulin
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR014745 MHC class II, alpha/beta chain, N-terminal
      IPR001003 MHC class II, alpha chain, N-terminal
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 8
      cDNA 21
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10408, MGD-MRK-10520
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 17
    • Earliest
      J:1569 Karlsson L, et al., The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex. J Exp Med. 1992 Aug 1;176(2):477-83
    • Latest
      J:342263 Song N, et al., Proper development of long-lived memory CD4 T cells requires HLA-DO function. Front Immunol. 2023;14:1277609
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory