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H2-Q10 Gene Detail
Summary
  • Symbol
    H2-Q10
  • Name
    histocompatibility 2, Q region locus 10
  • Synonyms
    H-2Q10, Q10, Qa10
  • Feature Type
    protein coding gene
  • IDs
    MGI:95929
    NCBI Gene: 15007
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:35780986-35785460 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.68 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1 from dbSNP Build 142
  • Strain Annotations
    12
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95929
 protein coding gene Chr17:35780986-35785460 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023639
 protein coding gene Chr17:35639989-35643332 (+)
A/J no annotation
AKR/J MGP_AKRJ_G0023596
 protein coding gene Chr17:35698802-35701985 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0023363
 protein coding gene Chr17:35118460-35123143 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024040
 protein coding gene Chr17:37052892-37064467 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0023341
 protein coding gene Chr17:38271448-38274694 (+)
DBA/2J MGP_DBA2J_G0023383
 protein coding gene Chr17:32150550-32153816 (-)
FVB/NJ MGP_FVBNJ_G0023438
 protein coding gene Chr17:33646659-33655504 (+)
LP/J MGP_LPJ_G0023547
 protein coding gene Chr17:35995668-35998873 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023459
 protein coding gene Chr17:37442708-37450010 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023999
 protein coding gene Chr17:33534592-33539964 (-)
PWK/PhJ MGP_PWKPhJ_G0022607
 protein coding gene Chr17:32711058-32717793 (+)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Vertebrate Orthologs
    20
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-A, major histocompatibility complex, class I, A
  • Synonyms
    HLAA
  • Links
    NCBI Gene ID: 3105
    neXtProt AC: NX_P04439
    UniProt: P04439

  • Chr Location
    6p22.1; chr6:29941260-29949572 (+)  GRCh38
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Synonyms
    AS, B-4901, HLAB
  • Links
    NCBI Gene ID: 3106
    neXtProt AC: NX_P01889
    UniProt: P01889

  • Chr Location
    6p21.33; chr6:31353872-31367067 (-)  GRCh38
  • Human Ortholog
    HLA-C, major histocompatibility complex, class I, C
  • Synonyms
    D6S204, HLAC, HLA-JY3, HLC-C, MHC, PSORS1
  • Links
    NCBI Gene ID: 3107
    neXtProt AC: NX_P10321
    UniProt: P10321

  • Chr Location
    6p21.33; chr6:31268749-31272130 (-)  GRCh38
  • Human Ortholog
    HLA-E, major histocompatibility complex, class I, E
  • Synonyms
    HLA-6.2, QA1
  • Links
    NCBI Gene ID: 3133
    neXtProt AC: NX_P13747
    UniProt: P13747

  • Chr Location
    6p22.1; chr6:30489509-30494194 (+)  GRCh38
  • Human Ortholog
    HLA-F, major histocompatibility complex, class I, F
  • Synonyms
    CDA12, HLA-5.4, HLA-CDA12, HLAF
  • Links
    NCBI Gene ID: 3134
    neXtProt AC: NX_P30511
    UniProt: P30511

  • Chr Location
    6p22.1; chr6:29722775-29738532 (+)  GRCh38
  • Human Ortholog
    HLA-G, major histocompatibility complex, class I, G
  • Synonyms
    MHC-G
  • Links
    NCBI Gene ID: 3135
    neXtProt AC: NX_P17693
    UniProt: P17693

  • Chr Location
    6p22.1; chr6:29826474-29831125 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Unlike other class I genes, this gene is expressed only in liver cells and its product is secreted into the serum. The amount of protein in serum varies among inbred strains with different H2 haplotypes and is completely absent in the H2f strain B10.M. Homozygous knockout affects conventional NK (cNK) cell and gamma-delta T cell development in the liver.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    73
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    23
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15007 NCBI Gene Model | MGI Sequence Detail 4475 C57BL/6J ±  kb
    transcript NM_010391 RefSeq | MGI Sequence Detail 1473 ZRU/MplStud  
    polypeptide P01898 UniProt | EBI | MGI Sequence Detail 325 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000008409 H-2 class I histocompatibility antigen, Q10 alpha chain
      (term hierarchy)
    • PDB
      5J6G, 5J6H
    • InterPro Domains
      IPR050208 Antigen-presenting and immune regulatory MHC class I-related
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR011162 MHC classes I/II-like antigen recognition protein
      IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
      IPR011161 MHC class I-like antigen recognition-like
      IPR037055 MHC class I-like antigen recognition-like superfamily
    • GlyGen
      P01898 2 sites
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 11
      cDNA 9
      Primer pair 1
      Other 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-10413, MGD-MRK-10525, MGD-MRK-13707, MGD-MRK-13719
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:20104 Steinmetz M, et al., Clusters of genes encoding mouse transplantation antigens. Cell. 1982 Mar;28(3):489-98
    • Latest
      J:313037 Goodall KJ, et al., Ribosylation of the CD8alphabeta heterodimer permits binding of the nonclassical major histocompatibility molecule, H2-Q10. J Biol Chem. 2021 Oct;297(4):101141
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory