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H2-T3 Gene Detail
Summary
  • Symbol
    H2-T3
  • Name
    histocompatibility 2, T region locus 3
  • Synonyms
    H-2T3, H2-Tw3, TL
  • Feature Type
    protein coding gene
  • IDs
    MGI:95959
    NCBI Gene: 15043
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:36496463-36501043 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 18.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95959
 protein coding gene Chr17:36496463-36501179 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0023626
 protein coding gene Chr17:35216090-35218268 (-)
AKR/J MGP_AKRJ_G0023598
 protein coding gene Chr17:35743062-35747775 (-)
BALB/cJ MGP_BALBcJ_G0023634
 protein coding gene Chr17:35466136-35472015 (-)
C3H/HeJ MGP_C3HHeJ_G0023396
 protein coding gene Chr17:36248333-36253046 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024072
 protein coding gene Chr17:37970047-37974762 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021543
 protein coding gene Chr17:32909649-32914393 (-)
CAST/EiJ MGP_CASTEiJ_G0022885
 protein coding gene Chr17:36283248-36287998 (-)
CBA/J MGP_CBAJ_G0023374
 protein coding gene Chr17:39554865-39559578 (-)
DBA/2J MGP_DBA2J_G0023498
 protein coding gene Chr17:34627425-34632558 (-)
FVB/NJ MGP_FVBNJ_G0023471
 protein coding gene Chr17:34383416-34388450 (-)
LP/J MGP_LPJ_G0023577
 protein coding gene Chr17:36851667-36857118 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023492
 protein coding gene Chr17:38180634-38186192 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024118
 protein coding gene Chr17:36042086-36046799 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0022954
 protein coding gene Chr17:36182511-36192815 (-)



Homology
more
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Vertebrate Orthologs
    10
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLA-B, major histocompatibility complex, class I, B
  • Synonyms
    AS, B-4901, HLAB
  • Links
    NCBI Gene ID: 3106
    neXtProt AC: NX_P01889
    UniProt: P01889

  • Chr Location
    6p21.33; chr6:31353872-31367067 (-)  GRCh38
  • Human Ortholog
    HLA-C, major histocompatibility complex, class I, C
  • Synonyms
    D6S204, HLAC, HLA-JY3, HLC-C, MHC, PSORS1
  • Links
    NCBI Gene ID: 3107
    neXtProt AC: NX_P10321
    UniProt: P10321

  • Chr Location
    6p21.33; chr6:31268749-31272130 (-)  GRCh38
  • Human Ortholog
    HLA-E, major histocompatibility complex, class I, E
  • Synonyms
    HLA-6.2, QA1
  • Links
    NCBI Gene ID: 3133
    neXtProt AC: NX_P13747
    UniProt: P13747

  • Chr Location
    6p22.1; chr6:30489509-30494194 (+)  GRCh38
Human Diseases
more
  • Diseases
    45 with human HLA-A,HLA-B,HLA-C,HLA-E,HLA-G associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 2 alleles in 1 genetic background
    9 phenotypes from multigenic genotypes
    8 phenotype references
This locus contains the sole gene encoding the thymic leukemia antigen or TL antigen in "b haplotype" mice such as C57BL/6. Mice homozygous for a targeted knock-out are viable with normal reproduction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    20
  • cDNA Data
    4
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15043 NCBI Gene Model | MGI Sequence Detail 4581 C57BL/6J ±  kb
transcript NM_008208 RefSeq | MGI Sequence Detail 2178 ZRU/MplStud  
polypeptide P14432 UniProt | EBI | MGI Sequence Detail 384 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    16 Sequences
  • Protein Ontology
    PR:000008413 H-2 class I histocompatibility antigen, TLA(B) alpha chain
    (term hierarchy)
  • InterPro Domains
    IPR050208 Antigen-presenting and immune regulatory MHC class I-related
    IPR003597 Immunoglobulin C1-set
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
    IPR011162 MHC classes I/II-like antigen recognition protein
    IPR001039 MHC class I alpha chain, alpha1 alpha2 domains
    IPR011161 MHC class I-like antigen recognition-like
    IPR037055 MHC class I-like antigen recognition-like superfamily
  • GlyGen
    P14432 4 sites
Molecular
Reagents
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  • All nucleic 31
    Genomic 25
    cDNA 4
    Primer pair 1
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-10441, MGD-MRK-10555
References
more
  • Summaries
    All 57
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:5845 Flaherty L, et al., The Tla locus: a new allele and antigenic specificity. J Immunol. 1977 Aug;119(2):571-5
  • Latest
    J:261393 Fahl SP, et al., Role of a selecting ligand in shaping the murine gammadelta-TCR repertoire. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1889-1894
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory