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Hadh Gene Detail
Summary
  • Symbol
    Hadh
  • Name
    hydroxyacyl-Coenzyme A dehydrogenase
  • Synonyms
    Hadhsc, Schad
  • Feature Type
    protein coding gene
  • IDs
    MGI:96009
    NCBI Gene: 15107
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:131027068-131065750 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 60.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1538 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96009
 protein coding gene Chr3:131027068-131065750 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027886
 protein coding gene Chr3:134029430-134068092 (-)
A/J MGP_AJ_G0027844
 protein coding gene Chr3:129302938-129341594 (-)
AKR/J MGP_AKRJ_G0027809
 protein coding gene Chr3:132671788-132712966 (-)
BALB/cJ MGP_BALBcJ_G0027857
 protein coding gene Chr3:129158952-129197618 (-)
C3H/HeJ MGP_C3HHeJ_G0027586
 protein coding gene Chr3:133077372-133117443 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028300
 protein coding gene Chr3:138750215-138788900 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025638
 protein coding gene Chr3:124821795-124862305 (-)
CAST/EiJ MGP_CASTEiJ_G0027042
 protein coding gene Chr3:132798103-132839222 (-)
CBA/J MGP_CBAJ_G0027562
 protein coding gene Chr3:143417057-143455707 (-)
DBA/2J MGP_DBA2J_G0027702
 protein coding gene Chr3:128506651-128545476 (-)
FVB/NJ MGP_FVBNJ_G0027669
 protein coding gene Chr3:126086145-126125931 (-)
LP/J MGP_LPJ_G0027812
 protein coding gene Chr3:135504096-135542778 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027700
 protein coding gene Chr3:151343370-151383447 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028358
 protein coding gene Chr3:132355947-132394628 (-)
PWK/PhJ MGP_PWKPhJ_G0026766
 protein coding gene Chr3:128250083-128290809 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026591
 protein coding gene Chr3:130396497-130436478 (-)
WSB/EiJ MGP_WSBEiJ_G0027121
 protein coding gene Chr3:133084975-133125390 (-)



Homology
more
  • Human Ortholog
    HADH, hydroxyacyl-CoA dehydrogenase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HADH, hydroxyacyl-CoA dehydrogenase
  • Synonyms
    HAD, HADH1, HADHSC, HCDH, HHF4, MSCHAD, SCHAD
  • Links
    NCBI Gene ID: 3033
    neXtProt AC: NX_Q16836
    UniProt: Q16836

  • Chr Location
    4q25
Human Diseases
more
  • Diseases
    1 with human HADH associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased susceptibility to diet-induced obesity associated with impaired fatty acid oxidation, impaired fat tolerance, decreased ketone bodies, and increased glucose-stimulated insulin secretion. Mice homozygous for a different null allele exhibit reduced male fertility associated with oligoasthenoteratozoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    966
  • Tissues
    166
  • cDNA Data
    205
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15107 NCBI Gene Model | MGI Sequence Detail 38683 C57BL/6J ±  kb
    transcript NM_008212 RefSeq | MGI Sequence Detail 1801 C57BL/6  
    polypeptide Q61425 UniProt | EBI | MGI Sequence Detail 314 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000008432 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.1.1.35
    • InterPro Domains
      IPR022694 3-hydroxyacyl-CoA dehydrogenase
      IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
      IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
      IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
      IPR013328 6-phosphogluconate dehydrogenase, domain 2
      IPR008927 6-phosphogluconate dehydrogenase-like, C-terminal domain superfamily
      IPR052242 Mitochondrial 3-hydroxyacyl-CoA dehydrogenase
      IPR036291 NAD(P)-binding domain superfamily
    • GlyGen
      Q61425 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 208
      cDNA 206
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10609, MGI:2139565, MGI:2139879, MGI:2140013
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 15
      Phenotypes 18
    • Earliest
      J:19568 Nomura M, et al., Isolation and characterization of retinoic acid-inducible cDNA clones in F9 cells: one of the early inducible clones encodes a novel protein sharing several highly homologous regions with a Drosophila polyhomeotic protein. Differentiation. 1994 Jun;57(1):39-50
    • Latest
      J:339012 St-Louis JL, et al., Deficiency of the metabolic enzyme SCHAD in pancreatic beta-cells promotes amino acid-sensitive hypoglycemia. J Biol Chem. 2023 Jun 29;299(8):104986
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory