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Hao1 Gene Detail
Summary
  • Symbol
    Hao1
  • Name
    hydroxyacid oxidase 1, liver
  • Synonyms
    GOX, Gox1, Hao-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96011
    NCBI Gene: 15112
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:134339281-134396272 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 65.65 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1346 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96011
 protein coding gene Chr2:134339281-134396288 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026552
 protein coding gene Chr2:138198613-138252574 (-)
A/J MGP_AJ_G0026516
 protein coding gene Chr2:132549226-132599617 (-)
AKR/J MGP_AKRJ_G0026490
 protein coding gene Chr2:136386800-136443217 (-)
BALB/cJ MGP_BALBcJ_G0026528
 protein coding gene Chr2:132975325-133027288 (-)
C3H/HeJ MGP_C3HHeJ_G0026271
 protein coding gene Chr2:136835950-136892469 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026973
 protein coding gene Chr2:142375170-142433180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024350
 protein coding gene Chr2:127200246-127248314 (-)
CAST/EiJ MGP_CASTEiJ_G0025732
 protein coding gene Chr2:137179690-137232014 (-)
CBA/J MGP_CBAJ_G0026251
 protein coding gene Chr2:147674524-147736100 (-)
DBA/2J MGP_DBA2J_G0026385
 protein coding gene Chr2:131927448-131978999 (-)
FVB/NJ MGP_FVBNJ_G0026349
 protein coding gene Chr2:130566519-130617967 (-)
LP/J MGP_LPJ_G0026489
 protein coding gene Chr2:138404212-138452705 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026369
 protein coding gene Chr2:151494081-151557962 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027028
 protein coding gene Chr2:136370316-136427026 (-)
PWK/PhJ MGP_PWKPhJ_G0025468
 protein coding gene Chr2:131537872-131588753 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025270
 protein coding gene Chr2:135508922-135558696 (-)
WSB/EiJ MGP_WSBEiJ_G0025806
 protein coding gene Chr2:137325661-137377064 (-)



Homology
more
  • Human Ortholog
    HAO1, hydroxyacid oxidase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAO1, hydroxyacid oxidase 1
  • Synonyms
    GO, GOX, GOX1, HAOX1
  • Links
    NCBI Gene ID: 54363
    neXtProt AC: NX_Q9UJM8
    UniProt: Q9UJM8

  • Chr Location
    20p12.3; chr20:7882985-7940458 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
Electrophoretic variants are known for this locus. The a allele determines a fast migrating band in BALB/c, CBA/H, C3H/He and C57BL/6; the b allele, a slow band in NZC; the c allele, the fastest band in DBA/Li, NFS/N, STS, 101/H and 129.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    18
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    16
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 15112 NCBI Gene Model | MGI Sequence Detail 56992 C57BL/6J ±  kb
transcript NM_010403 RefSeq | MGI Sequence Detail 2029 ZRU/MplStud  
polypeptide Q9WU19 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 16

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-10616, MGD-MRK-10618, MGI:1333886
References
more
  • Summaries
    All 71
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 9
    Phenotypes 27
  • Earliest
    J:5428 Duley J, et al., Alpha-hydroxyacid oxidase genetics in the mouse: evidence for two genetic loci and a tetrameric subunit structure for the liver isozyme. Genetics. 1974 Jan;76(1):93-7
  • Latest
    J:255430 Li X, et al., Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase. Biochim Biophys Acta. 2016 Feb;1862(2):233-9
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory