About   Help   FAQ
Hbegf Gene Detail
Summary
  • Symbol
    Hbegf
  • Name
    heparin-binding EGF-like growth factor
  • Synonyms
    Dtr, HB-EGF, Hegfl
  • Feature Type
    protein coding gene
  • IDs
    MGI:96070
    NCBI Gene: 15200
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:36637980-36648858 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.46 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96070
 protein coding gene Chr18:36637980-36648858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024278
 protein coding gene Chr18:34903354-34914220 (-)
A/J MGP_AJ_G0024244
 protein coding gene Chr18:33673702-33684611 (-)
AKR/J MGP_AKRJ_G0024212
 protein coding gene Chr18:34616178-34627046 (-)
BALB/cJ MGP_BALBcJ_G0024244
 protein coding gene Chr18:33724752-33735661 (-)
C3H/HeJ MGP_C3HHeJ_G0024011
 protein coding gene Chr18:34681050-34692139 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024685
 protein coding gene Chr18:36128736-36139608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022125
 protein coding gene Chr18:33768300-33779962 (-)
CAST/EiJ MGP_CASTEiJ_G0023486
 protein coding gene Chr18:34685308-34696157 (-)
CBA/J MGP_CBAJ_G0023979
 protein coding gene Chr18:37200375-37211284 (-)
DBA/2J MGP_DBA2J_G0024111
 protein coding gene Chr18:33297819-33308728 (-)
FVB/NJ MGP_FVBNJ_G0024078
 protein coding gene Chr18:33001243-33012113 (-)
LP/J MGP_LPJ_G0024193
 protein coding gene Chr18:34926641-34937510 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024106
 protein coding gene Chr18:38415127-38425997 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024734
 protein coding gene Chr18:34489807-34500676 (-)
PWK/PhJ MGP_PWKPhJ_G0023230
 protein coding gene Chr18:33544958-33555802 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023037
 protein coding gene Chr18:34737527-34749809 (-)
WSB/EiJ MGP_WSBEiJ_G0023549
 protein coding gene Chr18:34407038-34417905 (-)



Homology
more
  • Human Ortholog
    HBEGF, heparin binding EGF like growth factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HBEGF, heparin binding EGF like growth factor
  • Synonyms
    DTR, DTS, DTSF, HEGFL
  • Links
    NCBI Gene ID: 1839
    neXtProt AC: NX_Q99075
    UniProt: Q99075

  • Chr Location
    5q31.3; chr5:140332843-140346603 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human HBEGF associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 6 alleles in 6 genetic backgrounds
    16 phenotypes from multigenic genotypes
    3 images
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit grossly enlarged heart valves and ventricular chambers, and hypoplastic, immature lungs. Most mutants die by 3 weeks of age. Conditional deletion specifically in thge ventral forebrain results in behavior abnormalities and defects in pyramidal neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    54
  • cDNA Data
    32
  • Literature Summary
    40
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15200 NCBI Gene Model | MGI Sequence Detail 10879 C57BL/6J ±  kb
    transcript NM_010415 RefSeq | MGI Sequence Detail 2392 ZRU/MplStud  
    polypeptide Q06186 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 2
      cDNA 33
      Primer pair 7
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10692, MGI:2147342
    References
    more
    • Summaries
      All 142
      Developmental Gene Expression 40
      Gene Ontology 13
      Phenotypes 50
    • Earliest
      J:114809 Higashiyama S, et al., A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science. 1991 Feb 22;251(4996):936-9
    • Latest
      J:352937 Guild J, et al., Evidence for lung barrier regeneration by differentiation prior to binucleated and stem cell division. J Cell Biol. 2023 Dec 4;222(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory