About   Help   FAQ
Hhex Gene Detail
Summary
  • Symbol
    Hhex
  • Name
    hematopoietically expressed homeobox
  • Synonyms
    Hex, Hex1, Hhex-rs2, Prhx
  • Feature Type
    protein coding gene
  • IDs
    MGI:96086
    NCBI Gene: 15242
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:37423289-37429179 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 32.28 cM, cytoband D1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96086
 protein coding gene Chr19:37423258-37429179 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025081
 protein coding gene Chr19:36408965-36415148 (+)
A/J MGP_AJ_G0025057
 protein coding gene Chr19:34651052-34655974 (+)
AKR/J MGP_AKRJ_G0025025
 protein coding gene Chr19:35843135-35848054 (+)
BALB/cJ MGP_BALBcJ_G0025055
 protein coding gene Chr19:34739614-34744532 (+)
C3H/HeJ MGP_C3HHeJ_G0024814
 protein coding gene Chr19:35893508-35899077 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025496
 protein coding gene Chr19:37473920-37479922 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022915
 protein coding gene Chr19:34015555-34020514 (+)
CAST/EiJ MGP_CASTEiJ_G0024281
 protein coding gene Chr19:35738787-35749313 (+)
CBA/J MGP_CBAJ_G0024791
 protein coding gene Chr19:39209670-39214554 (+)
DBA/2J MGP_DBA2J_G0024923
 protein coding gene Chr19:34504731-34509659 (+)
FVB/NJ MGP_FVBNJ_G0024884
 protein coding gene Chr19:34315379-34320983 (+)
LP/J MGP_LPJ_G0025009
 protein coding gene Chr19:36506451-36513177 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024915
 protein coding gene Chr19:39017895-39023508 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025554
 protein coding gene Chr19:35919168-35924087 (+)
PWK/PhJ MGP_PWKPhJ_G0024033
 protein coding gene Chr19:34355596-34361562 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023833
 protein coding gene Chr19:34757315-34766734 (+)
WSB/EiJ MGP_WSBEiJ_G0024348
 protein coding gene Chr19:36005429-36010323 (+)



Homology
more
  • Human Ortholog
    HHEX, hematopoietically expressed homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HHEX, hematopoietically expressed homeobox
  • Synonyms
    HEX, HMPH, HOX11L-PEN, PRH, PRHX
  • Links
    NCBI Gene ID: 3087
    neXtProt AC: NX_Q03014
    UniProt: Q03014

  • Chr Location
    10q23.33; chr10:92689955-92695647 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    73 phenotypes from 7 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    2 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality associated with abnormal embryogenesis and cardiac development. Mice homozygous for another knock-out allele exhibit embryonic lethality, fetal lethality and abnormal nervous system development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    89
  • GO References
    29
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1213
  • Tissues
    270
  • cDNA Data
    28
  • Literature Summary
    171
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15242 NCBI Gene Model | MGI Sequence Detail 5891 C57BL/6J ±  kb
    transcript NM_008245 RefSeq | MGI Sequence Detail 1771 C57BL/6  
    polypeptide P43120 UniProt | EBI | MGI Sequence Detail 271 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 5
      cDNA 31
      Primer pair 10
      Other 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10715, MGI:1201390, MGI:1277985
    References
    more
    • Summaries
      All 242
      Developmental Gene Expression 171
      Gene Ontology 29
      Phenotypes 33
    • Earliest
      J:4210 Bedford FK, et al., HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human. Nucleic Acids Res. 1993 Mar 11;21(5):1245-9
    • Latest
      J:352077 Kane E, et al., MicroRNA-7 regulates endocrine progenitor delamination and endocrine cell mass in developing pancreatic islets. iScience. 2024 Jul 19;27(7):110332
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory