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Hmgn1 Gene Detail
Summary
  • Symbol
    Hmgn1
  • Name
    high mobility group nucleosomal binding domain 1
  • Synonyms
    Hmg14, HMG-14
  • Feature Type
    protein coding gene
  • IDs
    MGI:96120
    NCBI Gene: 15312
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95922788-95928925 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 56.83 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    47 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96120
 protein coding gene Chr16:95921818-95928929 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023080
 protein coding gene Chr16:97479718-97486868 (-)
A/J MGP_AJ_G0023048
 protein coding gene Chr16:92858175-92865624 (-)
AKR/J MGP_AKRJ_G0023018
 protein coding gene Chr16:95727371-95735313 (-)
BALB/cJ MGP_BALBcJ_G0023050
 protein coding gene Chr16:93415831-93422324 (-)
C3H/HeJ MGP_C3HHeJ_G0022811
 protein coding gene Chr16:96251349-96257366 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023497
 protein coding gene Chr16:100567456-100577962 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020999
 protein coding gene Chr16:90716785-90720530 (-)
CAST/EiJ MGP_CASTEiJ_G0022330
 protein coding gene Chr16:97041386-97046762 (-)
CBA/J MGP_CBAJ_G0022780
 protein coding gene Chr16:104908269-104916757 (-)
DBA/2J MGP_DBA2J_G0022914
 protein coding gene Chr16:92742456-92749817 (-)
FVB/NJ MGP_FVBNJ_G0022888
 protein coding gene Chr16:91920569-91926839 (-)
LP/J MGP_LPJ_G0022984
 protein coding gene Chr16:97114104-97122623 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022909
 protein coding gene Chr16:109140329-109146817 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023515
 protein coding gene Chr16:96258041-96265325 (-)
PWK/PhJ MGP_PWKPhJ_G0022075
 protein coding gene Chr16:93042753-93049968 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021905
 protein coding gene Chr16:95798451-95808298 (-)
WSB/EiJ MGP_WSBEiJ_G0022381
 protein coding gene Chr16:96524857-96531386 (-)



Homology
more
  • Human Ortholog
    HMGN1, high mobility group nucleosome binding domain 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGN1, high mobility group nucleosome binding domain 1
  • Synonyms
    HMG14
  • Links
    NCBI Gene ID: 3150
    neXtProt AC: NX_P05114
    UniProt: P05114

  • Chr Location
    21q22.2; chr21:39342315-39349647 (-)  GRCh38
Human Diseases
less
  • References
    6 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    115 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display partial embryonic lethality, increased cellular sensitivity to ultraviolet- and gamma-irradiation, increased tumor incidence and metastatic potential, increased incidence of ionizing radiation-induced tumors, and abnormal cell cycle checkpoint function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1113
  • Tissues
    278
  • cDNA Data
    14
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15312 NCBI Gene Model | MGI Sequence Detail 6138 C57BL/6J ±  kb
    transcript NM_008251 RefSeq | MGI Sequence Detail 1200 Not Specified  
    polypeptide P18608 UniProt | EBI | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      Genomic 3
      cDNA 15
      Primer pair 4
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-10756
    References
    more
    • Summaries
      All 165
      Developmental Gene Expression 17
      Diseases 6
      Gene Ontology 10
      Phenotypes 115
    • Earliest
      J:10494 Pash J, et al., Chromosomal protein HMG-14 gene maps to the Down syndrome region of human chromosome 21 and is overexpressed in mouse trisomy 16. Proc Natl Acad Sci U S A. 1990 May;87(10):3836-40
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory